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Original Contribution
May 19, 2010

Delivery of Evidence-Based Treatment for Multiple Anxiety Disorders in Primary Care: A Randomized Controlled Trial

Author Affiliations

Author Affiliations: Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Harborview Center for Healthcare Improvement for Addictions, Mental Illness, and Medically Vulnerable Populations (CHAMMP), Seattle, Washington (Drs Roy-Byrne and Welch); Departments of Psychology (Drs Craske and Rose) and Psychiatry and Biobehavioral Sciences (Dr Bystritsky), David Geffen School of Medicine, University of California, Los Angeles; Department of Psychiatry (Drs Sullivan and Edlund) and VA South Central Mental Illness Research, Education, and Clinical Center (Dr Sullivan), University of Arkansas for Medical Sciences, Little Rock; Departments of Psychiatry (Drs Lang, Chavira, Campbell-Sills, and Stein) and Family and Preventive Medicine (Dr Stein), University of California, San Diego; VA San Diego Health Care System Center of Excellence for Stress and Mental Health, San Diego, California (Dr Lang); and RAND Corporation, Santa Monica, California (Drs Sullivan, Golinelli, and Sherbourne).

JAMA. 2010;303(19):1921-1928. doi:10.1001/jama.2010.608

Context Improving the quality of mental health care requires moving clinical interventions from controlled research settings into real-world practice settings. Although such advances have been made for depression, little work has been performed for anxiety disorders.

Objective To determine whether a flexible treatment-delivery model for multiple primary care anxiety disorders (panic, generalized anxiety, social anxiety, and posttraumatic stress disorders) would be better than usual care (UC).

Design, Setting, and Patients A randomized controlled effectiveness trial of Coordinated Anxiety Learning and Management (CALM) compared with UC in 17 primary care clinics in 4 US cities. Between June 2006 and April 2008, 1004 patients with anxiety disorders (with or without major depression), aged 18 to 75 years, English- or Spanish-speaking, were enrolled and subsequently received treatment for 3 to 12 months. Blinded follow-up assessments at 6, 12, and 18 months after baseline were completed in October 2009.

Intervention CALM allowed choice of cognitive behavioral therapy (CBT), medication, or both; included real-time Web-based outcomes monitoring to optimize treatment decisions; and a computer-assisted program to optimize delivery of CBT by nonexpert care managers who also assisted primary care clinicians in promoting adherence and optimizing medications.

Main Outcome Measures Twelve-item Brief Symptom Inventory (BSI-12) anxiety and somatic symptoms score. Secondary outcomes included proportion of responders (≥50% reduction from pretreatment BSI-12 score) and remitters (total BSI-12 score <6).

Results A significantly greater improvement for CALM vs UC in global anxiety symptoms was found (BSI-12 group mean differences of −2.49 [95% confidence interval {CI}, −3.59 to −1.40], −2.63 [95% CI, −3.73 to −1.54], and −1.63 [95% CI, −2.73 to −0.53] at 6, 12, and 18 months, respectively). At 12 months, response and remission rates (CALM vs UC) were 63.66% (95% CI, 58.95%-68.37%) vs 44.68% (95% CI, 39.76%-49.59%), and 51.49% (95% CI, 46.60%-56.38%) vs 33.28% (95% CI, 28.62%-37.93%), with a number needed to treat of 5.27 (95% CI, 4.18-7.13) for response and 5.50 (95% CI, 4.32-7.55) for remission.

Conclusion For patients with anxiety disorders treated in primary care clinics, CALM compared with UC resulted in greater improvement in anxiety symptoms, depression symptoms, functional disability, and quality of care during 18 months of follow-up.

Trial Registration clinicaltrials.gov Identifier: NCT00347269