Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts | Critical Care Medicine | JAMA | JAMA Network
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Research Letter
July 2, 2014

Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts

Author Affiliations
  • 1Kaiser Permanente Division of Research, Oakland, California
  • 2Permanente Medical Group, Oakland, California
  • 3Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 4Associate Editor, JAMA
  • 5Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor
JAMA. 2014;312(1):90-92. doi:10.1001/jama.2014.5804

Sepsis, the inflammatory response to infection, affects millions of patients worldwide.1 However, its effect on overall hospital mortality has not been measured. We quantified the contribution of sepsis to mortality in 2 complementary inpatient cohorts from Kaiser Permanente Northern California (KPNC) and the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS).

The KPNC cohort included 482 828 adults (aged ≥18 years) with overnight, nonobstetrical hospitalizations at 21 KPNC hospitals between 2010 and 2012.2 Compared with all Northern California patients, KPNC patients have broadly similar health characteristics but higher income and educational attainment.3 The NIS, a nationally representative sample of 1051 hospitals, included 6.5 million unweighted adult hospitalizations in 2010.4