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October 15, 2014

The PCORI Perspective on Patient-Centered Outcomes Research

Lori Frank, PhD1; Ethan Basch, MD2; Joe V. Selby, MD, MPH1; et al For the Patient-Centered Outcomes Research Institute
Author Affiliations
  • 1Patient-Centered Outcomes Research Institute, Washington, DC
  • 2Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill
JAMA. 2014;312(15):1513-1514. doi:10.1001/jama.2014.11100

The Patient-Centered Outcomes Research Institute (PCORI) was established as part of the US Patient Protection and Affordable Care Act of 2010 to fund patient-centered comparative clinical effectiveness research, extending the concept of patient-centeredness from health care delivery to health care research. In the United States, patient-centered outcomes research is new and not defined in the legislation, and the rationale is unclear to many. In this Viewpoint, we address 2 related questions: What does patient-centeredness in research mean? Why conduct patient-centered outcomes research?

The essence of the PCORI definition of patient-centered outcomes research is the evaluation of questions and outcomes meaningful and important to patients and caregivers. The definition rests on the axiom that patients have unique perspectives that can change and improve the pursuit of clinical questions.