Customize your JAMA Network experience by selecting one or more topics from the list below.
Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-Associated Hospitalizations Among US Children, 1980-1996. JAMA. 1999;282(15):1440–1446. doi:10.1001/jama.282.15.1440
Author Affiliations: Respiratory and Enteric Viruses Branch (Drs Shay and Anderson) and Office of the Director (Mr Holman), Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga; Division of General Pediatrics, Department of Pediatrics, University of Washington School of Medicine, Seattle (Drs Newman, Liu, and Stout); and Department of Health Services, University of Washington School of Public Health and Community Medicine, Seattle (Dr Stout).
Context Respiratory syncytial virus (RSV) causes more lower respiratory tract
infections, often manifested as bronchiolitis, among young children than any
other pathogen. Few national estimates exist of the hospitalizations attributable
to RSV, and recent advances in prophylaxis warrant an update of these estimates.
Objectives To describe rates of bronchiolitis-associated hospitalizations and to
estimate current hospitalizations associated with RSV infection.
Design and Setting Descriptive analysis of US National Hospital Discharge Survey data from
1980 through 1996.
Participants Children younger than 5 years who were hospitalized in short-stay, nonfederal
hospitals for bronchiolitis.
Main Outcome Measure Bronchiolitis-associated hospitalization rates by age and year.
Results During the 17-year study period, an estimated 1.65 million hospitalizations
for bronchiolitis occurred among children younger than 5 years, accounting
for 7.0 million inpatient days. Fifty-seven percent of these hospitalizations
occurred among children younger than 6 months and 81% among those younger
than 1 year. Among children younger than 1 year, annual bronchiolitis hospitalization
rates increased 2.4-fold, from 12.9 per 1000 in 1980 to 31.2 per 1000 in 1996.
During 1988-1996, infant hospitalization rates for bronchiolitis increased
significantly (P for trend <.001), while hospitalization
rates for lower respiratory tract diseases excluding bronchiolitis did not
vary significantly (P for trend = .20). The proportion
of hospitalizations for lower respiratory tract illnesses among children younger
than 1 year associated with bronchiolitis increased from 22.2% in 1980 to
47.4% in 1996; among total hospitalizations, this proportion increased from
5.4% to 16.4%. Averaging bronchiolitis hospitalizations during 1994-1996 and
assuming that RSV was the etiologic agent in 50% to 80% of November through
April hospitalizations, an estimated 51,240 to 81,985 annual bronchiolitis
hospitalizations among children younger than 1 year were related to RSV infection.
Conclusions During 1980-1996, rates of hospitalization of infants with bronchiolitis
increased substantially, as did the proportion of total and lower respiratory
tract hospitalizations associated with bronchiolitis. Annual bronchiolitis
hospitalizations associated with RSV infection among infants may be greater
than previous estimates for RSV bronchiolitis and pneumonia hospitalizations
Create a personal account or sign in to: