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Chaix C, Durand-Zaleski I, Alberti C, Brun-Buisson C. Control of Endemic Methicillin-Resistant Staphylococcus aureus: A Cost-Benefit Analysis in an Intensive Care Unit. JAMA. 1999;282(18):1745–1751. doi:10.1001/jama.282.18.1745
Author Affiliations: Department of Public Health (Drs Chaix, Durand-Zaleski, and Alberti), the Infection Control Unit and Medical Intensive Care Unit, Hôpital Henri Mondor (Dr Brun-Buisson), Créteil, France.
Caring for the Critically Ill Patient Section Editor: Deborah J. Cook, MD, Consulting Editor, JAMA. Advisory Board: David
Bihari, MD; Christian Brun-Buisson, MD; Timothy Evans, MD; John Heffner, MD;
Norman Paradis, MD.
Context Despite the success of some countries in controlling endemic methicillin-resistant Staphylococcus aureus (MRSA), such programs have not been
implemented for some hospitals with endemic infection because of concerns
that these programs would be costly and of limited benefit.
Objective To compare the costs and benefits of an MRSA control program in an endemic
Design and Setting Case-control study conducted at a medical intensive care unit (ICU)
of a French university hospital with a 4% prevalence of MRSA carriage at ICU
Patients Twenty-seven randomly selected patients who had ICU-acquired MRSA infection
between January 1993 and June 1997, matched to 27 controls hospitalized during
the same period without MRSA infection.
Main Outcome Measures Intensive care unit costs attributable to MRSA infection, computed from
excess therapeutic intensity in cases using estimates from a cost model derived
in the same ICU, were compared with costs of the control program, derived
from time-motion study of nurses and physicians. The threshold for MRSA carriage
that would make the control strategy dominant was determined; sensitivity
analyses varied rates of MRSA transmission and ratio of infection to transmission,
length of ICU stay, and costs of isolation precautions.
Results The mean cost attributable to MRSA infection was US $9275 (median, $5885;
interquartile range, $1400-$16,720). Total costs of the control program ranged
from $340 to $1480 per patient. A 14% reduction in MRSA infection rate resulted
in the control program being beneficial. In sensitivity analyses, the control
strategy was dominant for a prevalence of MRSA carriage on ICU admission ranging
from 1% to 7%, depending on costs of control measures and MRSA transmission,
for infection rates greater than 50% following transmission.
Conclusions In this example of a hospital with endemic MRSA infection, selective
screening and isolation of carriers on ICU admission are beneficial compared
with no isolation.
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