Acute Effects of Passive Smoking on the Coronary Circulation in Healthy Young Adults | Tobacco and e-Cigarettes | JAMA | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.175.212.130. Please contact the publisher to request reinstatement.
1.
Taylor AE, Johnson DC, Kazemi H. Environmental tobacco smoke and cardiovascular disease: a position paper from the Council on Cardiopulmonary and Critical Care, American Heart Association.  Circulation.1992;86:699-702.Google Scholar
2.
Wells AJ. Passive smoking as a cause of heart disease.  J Am Coll Cardiol.1994;24:546-554.Google Scholar
3.
Kritz H, Scmidt P, Sinzinger H. Passive smoking and cardiovascular risk.  Arch Intern Med.1995;155:1942-1948.Google Scholar
4.
Glantz SA, Parmley WW. Passive smoking and heart disease: mechanisms and risk.  JAMA.1995;273:1047-1053.Google Scholar
5.
Steenland K, Thun M, Lally C, Health Jr C. Environmental tobacco smoke and coronary heart disease in American Cancer Society CPS-II cohort.  Circulation.1996;94:622-628.Google Scholar
6.
Kawachi I, Colditz GA, Speizer FE.  et al.  A prospective study of passive smoking and coronary heart disease.  Circulation.1997;95:2374-2379.Google Scholar
7.
Valkonen M, Kuusi T. Passive smoking induces atherogenic changes in low-density lipoprotein.  Circulation.1998;97:2012-2016.Google Scholar
8.
Celermajer DS, Adams MR, Clarkson P.  et al.  Passive smoking and impaired endothelium-dependent arterial dilation in healthy young adults.  N Engl J Med.1996;334:150-154.Google Scholar
9.
Fusejima K. Noninvasive measurement of coronary artery blood flow using combined two-dimensional and Doppler echocardiography.  J Am Coll Cardiol.1987;10:1024-1031.Google Scholar
10.
Ross Jr JJ, Mintz RG, Chandrasekaran K. Transthoracic two-dimensional high frequency (7.5 MHz) ultrasonic visualization of the distal left anterior coronary artery.  J Am Coll Cardiol.1990;15:373-377.Google Scholar
11.
Kenny A, Shapiro LM. Transthoracic high-frequency two-dimensional echocardiography, Doppler and color flow mapping to determine anatomy and blood flow patterns in the distal left anterior descending coronary artery.  Am J Cardiol.1992;69:1265-1268.Google Scholar
12.
Kenny A, Wisbey CR, Shapiro LM. Measurement of left anterior descending coronary artery flow velocities by transthoracic Doppler ultrasound.  Am J Cardiol.1994;73:1021-1022.Google Scholar
13.
Kenny A, Wisbey CR, Shapiro LM. Profiles of coronary blood flow velocity in patients with aortic stenosis and the effect of valve replacement: a transthoracic echocardiographic study.  Br Heart J.1994;71:57-62.Google Scholar
14.
Camiti P, Marraccini P, Marzilli M.  et al.  Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans.  Am J Physiol.1989;257:E309-E317.Google Scholar
15.
Nagamahci S, Czernin J, Kimm AS.  et al.  Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET.  J Nucl Med.1996;37:1626-1631.Google Scholar
16.
Sonoda S, Takeuchi M, Nakashima Y, Kuroiwa A. Safety and optimal dose of intracoronary adenosine 5'-triphosphate for the measurement of coronary flow reserve.  Am Heart J.1998;135:621-627.Google Scholar
17.
Holbrook JH, Grundy SM, Hennekens CH, Kannel WB, Strong JP. Cigarette smoking and cardiovascular diseases: a statement for health professionals by a task force appointed by the steering committee of the American Heart Association.  Circulation.1984;70:1114A-1117A.Google Scholar
18.
Zeiher AM, Schachinger V, Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function.  Circulation.1995;92:1094-1100.Google Scholar
19.
Folkov B. "Structural factor" in primary and secondary hypertension.  Hypertension.1990;16:89-101.Google Scholar
20.
Raij L, Nagy J, Jaimes E, Shultz P, DeMaster EG. Mechanisms of cigarette smoke induced impairment of endothelium dependent modulation of vascular tone [abstract].  Circulation.1994;90(suppl I):575.Google Scholar
21.
Zhu B-Q, Sun Y-P, Sievers RE, Isenberg WM, Glantz SA, Parmley WW. Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits.  J Am Coll Cardiol.1993;21:225-232.Google Scholar
22.
Penn A, Snyder CA. Inhalation of sidestream cigarette smoke accelerates development of arteriosclerotic plaques.  Circulation.1993;88:1820-1825.Google Scholar
23.
Penn A, Chen L-C, Snyder CA. Inhalation of steady-state sidestream smoke from one cigarette promotes arteriosclerotic plaque development.  Circulation.1994;90:1363-1367.Google Scholar
24.
Wells AJ. An estimate of adult mortality from passive smoking.  Environ Int.1988;14:249-265.Google Scholar
25.
Steenland K. Passive smoking and the risk of heart disease.  JAMA.1992;267:94-99.Google Scholar
26.
Schächinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease.  Circulation.2000;101:1899-1906.Google Scholar
27.
Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis.  Am J Cardiol.1974;33:87-92.Google Scholar
28.
De Silva R, Camici PG. Role of positron emission tomography in the investigation of human coronary circulatory function.  Cardiovasc Res.1994;28:1595-1612.Google Scholar
29.
Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schweiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography.  Circulation.1994;90:808-817.Google Scholar
30.
Miller DD, Donohue TJ, Wolford TL.  et al.  Assessment of blood flow distal to coronary artery stenoses: correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve.  Circulation.1996;94:2447-2454.Google Scholar
31.
Verberne HJ, Piek JJ, Van Liebergen RAM, Koch KT, Schroeder-Tanka JM, Van Royen EA. Functional assessment of coronary artery stenosis by Doppler derived absolute and relative coronary blood flow velocity reserve in comparison with (99m) Tc MIBI SPECT.  Heart.1999;82:509-514.Google Scholar
32.
Tanaka T, Oka Y, Tawara I, Sada T, Kira Y. Acute effects of nicotine content in cigarettes on coronary flow velocity and coronary flow reserve in men.  Am J Cardiol.1998;82:1275-1278.Google Scholar
33.
Sumida H, Watanabe H, Kugiyama K, Ohgushi M, Matsumura T, Yasue H. Dose passive smoking impair endothelium-dependent coronary artery dilation in women?  J Am Coll Cardiol.1998;31:811-815.Google Scholar
34.
Seiler C, Hess OM, Buechi M.  et al.  Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries.  Circulation.1993;88:2139-2148.Google Scholar
35.
Nitenberg A, Valensi P, Sachs R.  et al.  Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function.  Diabetes.1993;42:1017-1025.Google Scholar
36.
Frielingsdorf J, Seiler C, Kaufmann P.  et al.  Normalization of abnormal coronary vasomotion by calcium antagonists in patients with hypertension.  Circulation.1996;93:1380-1387.Google Scholar
37.
Hozumi T, Yoshida K, Ogata Y.  et al.  Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography.  Circulation.1998;97:1557-1562.Google Scholar
38.
Kaufmann PA, Gnecchi-Ruscone T, Di Terlizzi M, Schäfers KP, Lüscher TF, Camici PG. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function.  Circulation.2000;102:1233-1238.Google Scholar
39.
Glantz SA, Parmley WW. Passive smoking and heart disease: epidemiology, physiology, and biochemistry.  Circulation.1991;83:1-12.Google Scholar
40.
Allred EN, Bleecker ER, Chaitman BR.  et al.  Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease.  N Engl J Med.1989;321:1426-1432.Google Scholar
41.
Wilson RF, Laughlin DE, Ackell PH, Chilian WM.  et al.  Transluminal subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man.  Circulation.1985;72:82-92.Google Scholar
Clinical Investigation
July 25, 2001

Acute Effects of Passive Smoking on the Coronary Circulation in Healthy Young Adults

Author Affiliations

Author Affiliations: Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan.

JAMA. 2001;286(4):436-441. doi:10.1001/jama.286.4.436
Abstract

Context Recent studies have shown that passive smoking is a risk factor for ischemic heart disease and may be associated with vascular endothelial dysfunction. The acute effects of passive smoking on coronary circulation in nonsmokers are not known.

Objective To determine the acute effects of passive smoking on coronary circulation using coronary flow velocity reserve (CFVR), assessed by noninvasive transthoracic Doppler echocardiography.

Design, Setting, and Participants Cross-sectional study conducted from September 2000 to November 2000 among 30 Japanese men (mean age, 27 years; 15 healthy nonsmokers and 15 asymptomatic active smokers) without history of hypertension, diabetes mellitus, or hyperlipidemia.

Main Outcome Measures Coronary flow velocity reserve, calculated as the ratio of hyperemic to basal coronary flow velocity induced by intravenous infusion of adenosine triphosphate and measured in each participant before and after a 30-minute exposure to environmental tobacco smoke.

Results Heart rate and blood pressure responses to adenosine triphosphate infusion were not affected by passive smoking exposure in either group. Passive smoking exposure had no effect on basal coronary flow velocity in either group. Mean (SD) CFVR in nonsmokers was significantly higher than that in active smokers before passive smoking exposure (4.4 [0.91] vs 3.6 [0.88], respectively; P = .02), while CFVR after passive smoking exposure did not differ between groups (P = .83). Passive smoking exposure significantly reduced mean (SD) CFVR in nonsmokers (4.4 [0.91] vs 3.4 [0.73], respectively; P<.001).

Conclusions Passive smoking substantially reduced CFVR in healthy nonsmokers. This finding provides direct evidence that passive smoking may cause endothelial dysfunction of the coronary circulation in nonsmokers.

×