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Original Contribution
August 8, 2001

Invasive Meningococcal Disease in Adolescents and Young Adults

Author Affiliations

Author Affiliations: Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md (Dr Harrison and Mss Pass and Bustamante); Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine (Drs Harrison and Egri) and Department of Epidemiology, University of Pittsburgh; Graduate School of Public Health (Dr Mendelsohn), Pittsburgh, Pa; Meningitis and Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga (Dr Rosenstein); Laboratories Administration (Dr Razeq) and Epidemiology and Disease Control Program (Dr Roche), Maryland Department of Health and Mental Hygiene, Baltimore.
Dr Egri is now with the Department of Public Health, Inonu University School of Medicine, Malatya, Turkey.

JAMA. 2001;286(6):694-699. doi:10.1001/jama.286.6.694

Context Incidence of invasive meningococcal disease has increased recently in persons aged 15 through 24 years.

Objective To characterize meningococcal infection in adolescents and young adults in Maryland during the 1990s.

Design and Setting Population-based surveillance study for meningococcal disease from January 1, 1990, through December 31, 1999, in Maryland.

Patients Maryland residents diagnosed as having invasive meningococcal disease.

Main Outcome Measure Invasive meningococcal infection.

Results Of 295 total cases, 71 (24.1%) occurred among persons aged 15 through 24 years. Sixteen (22.5%) of these cases were fatal. The annual incidence rate increased from 0.9 to 2.1 cases per 100 000 among 15 through 24 year olds (P = .01). The proportion of all disease increased from 16.0% to 28.9% (P = .03). The incidence and proportion of cases subsequently decreased to 1.0 and 16.4% in 1998 through 1999, respectively. Infection in 15 through 24 year olds was more likely to be fatal than infection in those younger than age 15 years (22.5% vs 4.6%; P = .001). Infection in 15 through 24 year olds, compared with those aged 25 years or older, was more likely to be associated with male sex (66.2% vs 34.8%; P<.001) and serogroup C infection (46.9% vs 20.2%; P<.001), respectively. Infections were potentially preventable with the licensed meningococcal vaccine in 82.8% of 15 through 24 year olds, 68.1% of those younger than 15 years, and 76.8% of adults aged 25 years or older.

Conclusions Incidence of meningococcal infection in 15 through 24 year olds in Maryland increased and then declined during the 1990s. Infection in this age group was associated with an unusually high case-fatality ratio, and the vast majority of cases were potentially vaccine preventable.