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Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed
for the treatment of depression. Kroenke and colleaguesArticle compared the effectiveness
of initial treatment with 3 SSRIs—paroxetine, fluoxetine, and sertraline—in
a randomized trial among patients beginning antidepressant therapy in primary
care practices. During 9 months of follow-up, amelioration of depression and
improvements in other psychological, functional, and health-related quality-of-life
outcomes were not significantly different among the 3 treatment groups. In
an editorial, SimonArticle discusses selection of first-line antidepressant medication
and care after the initial prescription, noting that initial treatment with
any SSRI drug will not be successful in a substantial minority of patients.
This Week in JAMA. JAMA. 2001;286(23):2907. doi:10.1001/jama.286.23.2907
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