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In the Caring for the Critically Ill Patient article titled "High-Dose
Antithrombin III in Severe Sepsis: A Randomized Controlled Trial" published
in the October 17, 2001, issue of THE JOURNAL (2001;286:1869-1878), several
errors were printed. On page 1874 in the first column, second paragraph, the
sentence should read "Antithrombin III resulted in a 15% relative improvement
in 90-day mortality," not "absolute improvement." On page 1875, the title
of Table 3 should read "Incidence of New Organ Dysfunction According
to Logistic Organ Dysfunction Score. . . . " Also on page 1875, the legend
for Figure 5 should indicate that the patients represented in the graph are
the percentage discharged alive from ICU in relation to all patients (surviving
and dead). On page 1876, the footnote to Table 4 was inadvertently omitted.
It should have read "Number of patients actually treated with antithrombin
III or placebo." This footnote clarifies the different patient numbers for
the primary efficacy analysis (n = 1157 per group) vs the safety analysis
(placebo: n = 1155; antithrombin III: n = 1161). On page 1876, the top paragraph
in the third column should end with this sentence: "Up to and beyond the second
interim analysis, an overall nominal survival benefit for antithrombin III
prevailed, despite the recognized increased bleeding risk in that group."
Incorrect Wording and Omissions. JAMA. 2002;287(2):192. doi:10.1001/jama.287.2.192
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