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The relationship between environmental exposures early in life and subsequent
development of allergic disease is not well understood. In this prospective
birth cohort study, Ownby and colleaguesArticle found that risk of allergic sensitization
to common aeroallergens at age 6 to 7 years was lower among children exposed
to 2 or more dogs or cats in the first year of life than among children exposed
to 1 dog or cat or those without any early dog or cat exposure. In an editorial,
Platts-MillsArticle discusses immunologic mechanisms that may explain the different
associations that have been observed between allergen exposure and risk of
allergic sensitization and disease.
This Week in JAMA. JAMA. 2002;288(8):923. doi:10.1001/jama.288.8.923
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