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Schober SE, Sinks TH, Jones RL, et al. Blood Mercury Levels in US Children and Women of Childbearing Age, 1999-2000. JAMA. 2003;289(13):1667–1674. doi:10.1001/jama.289.13.1667
Author Affiliations: National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Md (Drs Schober and Dillon, and Ms McDowell); National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga (Drs Sinks, Jones, and Osterloh); Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Md (Drs Bolger and Canady); National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Pascagoula, Miss (Mr Garrett); The Orkand Corporation, Falls Church, Va (Dr Sun); and Office of Science Coordination and Policy, Office of Prevention, Pesticides, and Toxic Substances, Environmental Protection Agency, Washington, DC (Dr Mahaffey and Ms Joseph). Dr Sun is now with Chiacchierini & Associates, LLC, Rockville, Md.
Context Humans are exposed to methylmercury, a well-established neurotoxin,
through fish consumption. The fetus is most sensitive to the adverse effects
of exposure. The extent of exposure to methylmercury in US women of reproductive
age is not known.
Objective To describe the distribution of blood mercury levels in US children
and women of childbearing age and the association with sociodemographic characteristics
and fish consumption.
Design and Setting The 1999-2000 data from the National Health and Nutrition Examination
Survey, a cross-sectional survey of the noninstitutionalized US population.
Participants In 1999-2000, 1250 children aged 1 to 5 years and 2314 women aged 16
to 49 years were selected to participate in the survey. Household interviews,
physical examinations, and blood mercury levels assessments were performed
on 705 children (56% response rate) and 1709 women (74% response rate).
Main Outcome Measure Blood concentration of total mercury.
Results Blood mercury levels were approximately 3-fold higher in women compared
with children. The geometric mean concentration of total blood mercury was
0.34 µg/L (95% confidence interval [CI], 0.30-0.39 µg/L) in children
and 1.02 µg/L (95% CI, 0.85-1.20 µg/L) in women. Geometric mean
mercury levels were almost 4-fold higher among women who ate 3 or more servings
of fish in the past 30 days compared with women who ate no fish in that period
(1.94 µg/L vs 0.51 µg/L; P<.001).
Conclusions Measures of mercury exposure in women of childbearing age and young
children generally fall below levels of concern. However, approximately 8%
of women had concentrations higher than the US Environmental Protection Agency's
recommended reference dose (5.8 µg/L), below which exposures are considered
to be without adverse effects. Women who are pregnant or who intend to become
pregnant should follow federal and state advisories on consumption of fish.
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