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News From the Centers for Disease Control and Prevention
July 2, 2003

Multistate Outbreak of Monkeypox— Illinois, Indiana, and Wisconsin, 2003

JAMA. 2003;290(1):30-31. doi:10.1001/jama.290.1.30

MMWR. 2003;52:537-540

1 table, 2 figures omitted

CDC has received reports of patients with a febrile rash illness who had close contact with pet prairie dogs and other animals. The Marshfield Clinic, Marshfield, Wisconsin, identified a virus morphologically consistent with a poxvirus by electron microscopy of skin lesion tissue from a patient, lymph node tissue from the patient's pet prairie dog, and isolates of virus from culture of these tissues. Additional laboratory testing at CDC indicated that the causative agent is a monkeypox virus, a member of the orthopoxvirus group. This report summarizes initial descriptive epidemiologic, clinical, and laboratory data, interim infection-control guidance, and new animal import regulations.