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Hypertension is a risk factor for progression of coronary artery disease
(CAD). Pepine and colleaguesArticle conducted a randomized
controlled trial among patients aged 50 years or older with hypertension and
CAD to compare outcomes of 2 multidrug blood pressure management strategies:
a verapamil-trandolapril–based strategy and an atenolol-hydrochlorothiazide–based
strategy. During a mean follow-up of 2.7 years, there were no significant
differences in the primary composite outcome of all-cause mortality, nonfatal
myocardial infarction, or nonfatal stroke between the treatment strategies.
In an editorial, AldermanArticle discusses ways to improve
cardiovascular disease prevention in both research studies and clinical practice.
The benefits of solitary pancreas transplant for diabetes mellitus remains
controversial. Venstrom and colleaguesArticle compared the
posttransplantation survival of patients with preserved renal function who
received either a pancreas alone or a pancreas-after-kidney transplant with
similar patients on the organ donor wait list during 1995-2000. After 4 years
of follow-up, patients who received a solitary pancreas transplant had worse
survival compared with patients who continued to receive conventional insulin
therapy. In a commentary, NathanArticle discusses the known
risks and benefits of isolated pancreas transplantation and urges diligent
attention to patient selection criteria.
This Week in JAMA. JAMA. 2003;290(21):2769. doi:10.1001/jama.290.21.2769
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