Customize your JAMA Network experience by selecting one or more topics from the list below.
Flannery B, Schrag S, Bennett NM, et al. Impact of Childhood Vaccination on Racial Disparities in Invasive Streptococcus pneumoniae Infections. JAMA. 2004;291(18):2197–2203. doi:10.1001/jama.291.18.2197
Author Affiliations Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, Ga (Drs Flannery, Schrag, Facklam, and Whitney and Ms Zell); Monroe County Department of Health and University of Rochester, Rochester, NY (Dr Bennett); Minnesota Department of Health, Minneapolis (Dr Lynfield); Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md (Dr Harrison); School of Public Health, University of California, Berkeley (Dr Reingold); Oregon Department of Human Service, Office of Disease Prevention and Epidemiology, Portland (Dr Cieslak); Connecticut Department of Public Health, Hartford (Dr Hadler); Emory University School of Medicine and the Veterans Affairs Medical Center, Atlanta, Ga (Dr Farley).
Context Historically, incidence of pneumococcal disease in the United States
has been higher among blacks than among whites. Following recommendation of
a new 7-valent pneumococcal conjugate vaccine for children in October 2000,
the incidence of invasive pneumococcal disease has declined dramatically,
but the impact of vaccination on racial disparities in incidence of pneumococcal
disease is unknown.
Objective To assess the effect of conjugate vaccine introduction on rates of pneumococcal
disease among whites and blacks in the United States.
Design, Setting, and Patients Analysis of data from the Active Bacterial Core Surveillance (ABCs)/Emerging
Infections Program Network, an active, population-based surveillance system
in 7 states. Patients were 15 923 persons with invasive pneumococcal
disease occurring between January 1, 1998, and December 31, 2002.
Main Outcome Measures Age- and race-specific pneumococcal disease incidence rates (cases per
100 000 persons), rate ratios, and rate differences.
Results Between 1998 and 2002, annual incidence rates for invasive pneumococcal
disease decreased from 19.0 to 12.1 cases per 100 000 among whites and
from 54.9 to 26.5 among blacks. Due to these declines, 14 730 fewer cases
occurred among whites and 8780 fewer cases occurred among blacks in the United
States in 2002, compared with 2 prevaccine years, 1998 and 1999. Before vaccine
introduction, incidence among blacks was 2.9 times higher than among whites
(95% confidence interval [CI], 2.7-3.0); in 2002, the black-white rate ratio
had been reduced to 2.2 (95% CI, 2.0-2.4). Incidence among black children
younger than 2 years went from being 3.3 times higher (95% CI, 3.0-3.7) than
among white children in the prevaccine period to 1.6 times higher (95% CI,
1.1-2.2) in 2002. By 2002, 74% of white children and 68% of black children
aged 19 to 35 months in the 7 states had received at least 1 dose of pneumococcal
conjugate vaccine; 43% of white and 39% of black children received 3 or more
Conclusion Although blacks remain at higher risk of invasive pneumococcal disease,
introduction of childhood pneumococcal vaccination has reduced the racial
disparity in incidence of pneumococcal disease.
Create a personal account or sign in to: