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2 figures, 2 tables omitted
Because syphilis infection facilitates acquisition and transmission
of human immunodeficiency virus (HIV),1,2 recent
outbreaks of syphilis among men who have sex with men (MSM) in major U.S.
cities,3 including San Francisco and Los
Angeles,4,5 and reported
increases in sexual risk behavior5 have
raised concerns about potential increases in HIV transmission. In 2002, MSM
accounted for the majority of primary and secondary (P&S) syphilis cases
in men reported in San Francisco (93%) and Los Angeles (81%). To investigate
a potential change in HIV incidence associated with the syphilis outbreaks
in the two cities, local, state, and federal health officials analyzed data
from HIV counseling and testing centers and a municipal sexually transmitted
disease (STD) clinic. This report describes the results of that investigation,
which indicated that, as of 2002, the outbreaks of syphilis had not had a
substantial impact on HIV incidence among MSM in these two cities. However,
the continued increase in syphilis cases in MSM underscores the need for integrated
HIV- and STD-prevention strategies to control syphilis outbreaks and prevent
potential increases in HIV infections6,7 and
for further systematic studies of HIV incidence among MSM infected with syphilis.
For this analysis, numbers and characteristics of P&S syphilis cases
among MSM in San Francisco and Los Angeles were determined from STD morbidity
data. Rates of P&S syphilis per 100,000 MSM were calculated for the estimated
50,782 MSM living in San Francisco in 2001.8 In
2002, approximately 47% and 18% of MSM with P&S syphilis in San Francisco
and Los Angeles, respectively, had syphilis diagnosed at publicly funded sites,
which included primarily STD clinics.
A sensitive/less sensitive HIV-1 enzyme immunoassay (EIA) (Vironostika
HIV-1 Microelisa, bioMérieux, Durham, North Carolina) testing algorithm
known as STARHS9,10 was
used to estimate HIV incidence by using stored blood specimens for (1) MSM
receiving confidential HIV counseling and testing at the City Clinic (SFCC),
San Francisco's only municipal STD clinic, and (2) MSM receiving anonymous
HIV counseling and testing at University of California at San Francisco AIDS
Health Project (AHP) sites. For persons tested at AHP sites (1998-2002) and
persons tested at SFCC (1998-2000), demographic and risk-factor information
collected on the California HIV counseling and testing form was analyzed.
For persons tested at SFCC (2001-2002), analogous information obtained from
medical records was analyzed. Persons who tested reactive with the sensitive
EIA and nonreactive with the less sensitive assay were considered recently
HIV infected (mean seroconversion period: 170 days).10 Annualized
HIV incidence and 95% confidence intervals (CIs) based on a normal distribution
were calculated; all reported p-values were obtained by using a chi-square
test for trend.
In Los Angeles, data from the California and CDC HIV counseling and
testing forms were used to calculate the percentages and characteristics of
MSM with newly diagnosed infections. These patients had received a confidential
or anonymous HIV test at publicly funded sites during 1998-2002.
During 1998-2002, the number of P&S syphilis cases among MSM in
San Francisco increased from four to 260, and the P&S syphilis rate increased
from eight to 512 per 100,000 MSM. In 2002, the median age of MSM P&S
syphilis patients was 38 years; 70% were white, 14% were Hispanic, and 61%
were HIV-infected. P&S syphilis cases among MSM at the SFCC also increased,
from four in 1998 to 106 in 2002.
MSM receiving HIV testing had similar demographic characteristics and
the two San Francisco testing populations. In 2002, at AHP and SFCC, respectively,
the median age of these patients was 34 and 33 years; 70% and 61% were white,
3% and 6% were black, 11% and 19% were Hispanic, 12% and 14% were Asian/Pacific
Islander (A/PI), and 4% and <1% were of other race/ethnicity.
Estimated HIV incidence among MSM who were tested in San Francisco was
highest in 1999 and tended to decline from 1999 to 2002 at both sites; however,
the trends were not statistically significant (p = 0.13 for AHP; p = 0.36
for SFCC). When injection-drug–using MSM were excluded from analyses,
HIV incidence was lower (e.g., in 2002, incidence was 2.3% [95% CI = 1.0-3.5]
at AHP and 3.3% [95% CI = 1.9-4.7] at SFCC), but temporal trends in HIV incidence
were similar. Median age of the 42 MSM with incident HIV infection at these
testing sites in 2002 was 32 years; 23 (55%) were white, and 12 (29%) were
HIV incidence was estimated by STARHS for men who had P&S syphilis
diagnosed at SFCC in 2002 and 2003 and who accepted confidential HIV-antibody
and STARHS testing. Of 74 men, 16 (22%) were HIV seropositive, and four (25%)
of these had a recent HIV infection identified by STARHS; all four of these
patients reported having had HIV-seronegative test results within the previous
2 years. On the basis of STARHS, estimated HIV incidence in this population
was 13.9% per year (95% CI = 0.3-27.5).
During 2000-2002, P&S syphilis cases among MSM in Los Angeles County
increased from 67 to 299, accounting for the majority of male syphilis patients.
In 2002, median age of MSM with P&S syphilis was 37 years; 51% were white,
31% were Hispanic, and 58% were HIV infected.
MSM receiving HIV testing at Los Angeles County sites had similar demographic
characteristics during 1998-2002. In 2002, the median age of 15,161 MSM who
were tested was 32 years; 42% were white, 10% were black, 37% were Hispanic,
7% were A/PI, and 4% were of other race/ethnicity. The percentage of MSM with
HIV newly diagnosed (i.e., without any previous HIV-positive test) decreased
from 4.8% (608 of 12,693) in 1998 to 4.1% (615 of 15,161) in 2002 (p<0.001).
In 2002, the 615 MSM who had newly diagnosed HIV had a median age of 32 years;
29% were white, 18% were black, and 45% were Hispanic. However, among MSM
who had an HIV-negative test result within the previous 12 months, the percentage
of men with a new HIV-positive test increased from 2.4% (102 of 4,196) in
1998 to 2.9% (186 of 6,446) in 2002 (p = 0.37).
JW Dilley, San Francisco AIDS Health Project; JD Klausner, MD, W McFarland,
PhD, TA Kellogg, MA, R Kohn, MPH, W Wong, MD, BT Louie, San Francisco Dept
of Public Health; MM Taylor, MD, PR Kerndt, MD, J Carlos, MPH, CR Chavers,
MSPH, Los Angeles County Dept of Public Health, Los Angeles; G Bolan, MD,
California Dept of Health Svcs. SD Holmberg, MD, AE Greenberg, MD, RH Byers,
PhD, Div of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention;
KA Buchacz, PhD, P Patel, MD, JB King, MD, EIS officers, CDC.
The number of new HIV infections among MSM at public HIV-testing sites
in San Francisco and Los Angeles did not increase during 1999-2002, a period
when syphilis cases among MSM increased substantially in both cities. Within
the SFCC population, no temporal correlation was detected between an increase
in the number of MSM P&S syphilis cases and the rates of new HIV infections
among MSM who received HIV testing at this STD clinic. Whether the syphilis
outbreaks are sentinel events indicating increased risk behavior that could
eventually result in increased HIV incidence is not known.
The findings of this ecological analysis are subject to at least five
limitations. First, whereas the overall P&S syphilis morbidity data were
reported from both private and public providers, with the majority of MSM
P&S syphilis cases being reported from private sources, HIV incidence
(San Francisco) and new HIV diagnoses (Los Angeles) could be examined only
for select populations at publicly funded HIV-testing sites. MSM attending
public HIV-testing venues might differ in their demographics and risk behaviors
from MSM who seek HIV testing from private providers or who have not been
HIV tested. Second, changes in testing practices and number and characteristics
of MSM in the two public HIV-testing populations might weaken inferences about
trends in HIV incidence or new HIV diagnoses among these populations. Analyses
might include persons who tested anonymously and repeatedly at SFCC, AHP,
and Los Angeles HIV-testing sites, and potential changes in repeat HIV-testing
patterns over time could affect HIV incidence trends. Third, the proportion
of oral HIV antibody tests performed for MSM at AHP sites increased from 11%
in 1998 to 36% in 2002, thus increasing the proportion of patients tested
who were excluded from STARHS-based estimates of HIV incidence. Fourth, STARHS
might misclassify a small percentage of persons with long-standing infection
as recently infected and vice versa.9,10 Finally,
the SFCC estimate of HIV incidence among MSM with P&S syphilis (13.9%
per year) has wide associated variability (95% CI = 0.3-27.5) and must be
interpreted with caution because not all male syphilis patients accepted HIV
Despite the high HIV incidence in men with P&S syphilis, HIV incidence
rates among MSM tested at large public sites in San Francisco and Los Angeles
did not increase during 1999-2002. This stability likely is because (1) the
number of new syphilis cases is small compared with the numbers of MSM at
risk for HIV infection and (2) in both cities more than half of the MSM P&S
syphilis patients had longstanding HIV infection before they acquired syphilis.
However, if the outbreaks of syphilis continue unabated, HIV incidence among
MSM at public HIV-testing sites and in the larger MSM community might increase.
Recommendations include behavioral risk assessment, frequent STD screening,
and prompt treatment of syphilis in HIV-infected persons and their partners
to control syphilis outbreaks and prevent a potential increase in HIV infections.
Trends in Primary and Secondary Syphilis and HIV Infections in Men Who Have Sex With Men—San Francisco and Los Angeles, California, 1998-2002. JAMA. 2004;292(8):917–918. doi:10.1001/jama.292.8.917
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