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October 5, 2005

Genetic Influences on Health: Does Race Matter?—Correction

JAMA. 2005;294(13):1620. doi:10.1001/jama.294.13.1620

Incorrect Figure: In the Special Communication entitled “Genetic Influences on Health: Does Race Matter?” published in the August 24/31, 2005, issue of JAMA (2005;294:937-946), there is an error in Figure 1. The colors for the distributions below the curve were reversed; the key to the Figure is correct. The correct Figure 1 appears below.

Figure 1. Hypothetical Relationship Between Genetic Risk, Ancestry, and Race
Image description not available.

Distributions of the reduction in blood pressure observed in African Americans and European Americans after treatment with an angiotensin-converting enzyme (ACE) inhibitor. One hypothetical explanation for the mean difference in treatment response is that a genetic risk variant predictive of a positive response to treatment is more common in European Americans (individuals to the right of the dotted line) than in African Americans. Note, however, that some African Americans also have the genetic risk variant and that many African Americans and European Americans who do not have the genetic risk variant have a similar response to treatment (ie, overlap between distributions). In this case, race might not be considered a good predictor of genetic risk or response to treatment. Based on an original concept by Seghal.9