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This Week in JAMA
February 1, 2006

This Week in JAMA

JAMA. 2006;295(5):469. doi:10.1001/jama.295.5.469

Although supporting evidence is limited, the emotional well-being common during pregnancy is often thought to provide protection from psychiatric disorders during the prenatal period. In a prospective longitudinal study of depression during pregnancy, Cohen and colleagues assessed risk of depression relapse in women who discontinued antidepressant medication compared with women who continued antidepressant use. The authors found that 43% of the women experienced a relapse of depression during pregnancy. Twenty-six percent of women who maintained their medication throughout pregnancy relapsed compared with 68% of women who discontinued medication.


Bone marrow transplantation using stem cells from a related HLA-identical donor is the preferred treatment for patients with severe combined immune deficiency (SCID). For patients without a related HLA-identical donor, information on the efficacy and safety of alternative donor strategies is needed. Grunebaum and colleagues reviewed outcomes of patients with SCID receiving stem cells from related HLA-identical donors, HLA-mismatched related donors, and HLA-matched unrelated donors. The authors found that among patients without a related, identical donor, those who received an HLA-matched unrelated transplant had superior engraftment, immune reconstitution, and survival and a higher risk of acute graft-vs-host disease than patients who received a graft from an HLA-mismatched related donor.