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This Week in JAMA
September 20, 2006

This Week in JAMA

JAMA. 2006;296(11):1323. doi:10.1001/jama.296.11.1323

Induced preterm delivery is common in pregnancies complicated by preeclampsia, but little is known about the effects of early delivery on fetal and infant survival. Basso and colleagues analyzed data from 1967 to 2003 for singleton first-born infants of Norwegian-born mothers to assess fetal and infant survival following early delivery of preeclamptic pregnancies. Comparing data from 1967-1978 with that from 1991-2003, the authors found a significant increase in the rate of preterm inductions for preeclampsia, a reduction in the risk of stillbirth in preeclamptic vs nonpreeclamptic pregnancies, and relatively stable risks of neonatal and later infant deaths.


Whether lipoprotein(a) is a meaningful marker of cardiovascular risk in women is controversial, and part of the controversy could be a consequence of interassay differences. To explore these questions, Suk Danik and colleagues used a state-of-the-art lipoprotein(a) assay to assess the association between baseline lipoprotein(a) levels and incidence of future cardiovascular events in a prospective cohort study of 27 791 women who were healthy at study enrollment. The authors found a significantly increased risk of future cardiovascular events among women with extremely high (≥90th percentile) levels of lipoprotein(a), particularly among women with high levels of low-density lipoprotein cholesterol.