Outcomes of Fresh and Cryopreserved Oocyte Donation | Pathology and Laboratory Medicine | JAMA | JAMA Network
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Research Letter
August 11, 2015

Outcomes of Fresh and Cryopreserved Oocyte Donation

Author Affiliations
  • 1Center for Human Reproduction, New York, New York
JAMA. 2015;314(6):623-624. doi:10.1001/jama.2015.7556

Use of oocytes donated for in vitro fertilization (IVF) has increased in recent years.1 Donated fresh oocytes traditionally have been used immediately, creating embryos for transfer into the uterus, with extra embryos being cryopreserved for later use. In January 2013, the American Society for Reproductive Medicine declared the technique of oocyte cryopreservation (egg freezing) no longer experimental, although it called for “more widespread clinic-specific data on the safety and efficacy of oocyte cryopreservation … before universal donor oocyte banking can be recommended.”2

Based on data that IVF outcomes with cryopreserved and fresh donor oocytes are comparable,3 some IVF centers established frozen donor egg banks. However, data reflecting IVF outcomes in routine clinical practice with cryopreserved donor oocytes have not been published.