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In This Issue of JAMA
August 25, 2015


JAMA. 2015;314(8):747-749. doi:10.1001/jama.2014.11935

Epidemiologic evidence supports an association of regular physical activity with lower rates of cognitive decline. Sink and colleagues investigated this relationship in a clinical trial involving 1635 community-dwelling sedentary adults aged 70 to 89 years who were randomly assigned to a 24-month structured, moderate-intensity physical activity program or to a health education program. The authors report that compared with health education, the 24-month physical activity program did not result in improvements in global or domain-specific cognitive function. In an Editorial, Gill and Seitz discuss lifestyle factors and cognitive health.

Editorial and Related Article

Author Video Interview

High dietary intake of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) and antioxidants has been associated with better cognitive performance in observational studies. Chew and colleagues assessed 5-year change in cognitive function test scores in 3073 participants in the Age-Related Eye Disease Study 2, who received varying combinations of vitamins C and E, beta-carotene, and zinc were randomly assigned to receive LCPUFAs and lutein/zeaxanthin or placebo. The authors report that among older persons with age-related macular degeneration, LCPUFA and lutein/zeaxanthin supplements did not affect cognitive function.