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Sartipy U, Holzmann MJ, Hjalgrim H, Edgren G. Red Blood Cell Concentrate Storage and Survival After Cardiac Surgery. JAMA. 2015;314(15):1641–1643. doi:10.1001/jama.2015.8690
Blood undergoes several physiological changes during storage. Observational studies have suggested that transfusion of stored red blood cell (RBC) concentrates may be harmful1; however, the results are inconsistent.2 We performed a nationwide cohort study of RBC storage and adverse outcomes after cardiac surgery.
We identified all patients who underwent coronary artery bypass graft surgery, heart valve surgery, or both between 1997 and 2012 from the SWEDEHEART register, which records information on patients who undergo heart surgery in Sweden.3 Transfusion data were obtained from the SCANDAT2 database, a nationwide register of blood transfusions.4 Linkage with national health data registers provided vital status and adverse outcomes.
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