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In This Issue of JAMA
November 17, 2015


JAMA. 2015;314(19):1999-2001. doi:10.1001/jama.2014.12089

Many children develop recurrent, severe episodes of lower respiratory tract illness (LRTI), often related to viral infection, although bacterial infection may also contribute. In a randomized placebo-controlled trial involving 607 young children who had a history of recurrent, severe LRTI, Bacharier and colleagues found that early use of azithromycin during an apparent respiratory tract illness reduced the likelihood of progression to severe LRTI. In an Editorial, Cohen and Pelton contrast individual benefit with potential adverse societal consequences of antibiotic use for pediatric LRTI.

Author Video Interview


To improve patient selection for percutaneous coronary intervention (PCI), the Appropriate Use Criteria for Coronary Revascularization were developed and published in 2009. In an analysis of registry data from 2.7 million PCI procedures performed between July 1, 2009, and December 31, 2014, Desai and colleagues found that since publication of the criteria, there have been significant reductions in the volume of nonacute PCI procedures and in the proportion of nonacute PCIs classified as inappropriate. Hospital-level variation in inappropriate PCI persists. In an Editorial, Harrington discusses efforts to ensure appropriate use of coronary revascularization.