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The effect of red blood cell (RBC) storage duration on tissue oxygenation by transfused RBCs is uncertain. In a randomized, noninferiority trial involving 290 Ugandan children with lactic acidosis due to severe anemia, Dhabangi and colleagues found that transfusion of RBC units stored for 25 to 35 days compared with those stored for 1 to 10 days did not result in inferior reduction of elevated blood lactate levels—a surrogate of tissue oxygenation—assessed 8 hours after transfusion. In an Editorial, Spinella and Acker discuss the need for quality metrics to ensure the efficacy and safety of transfused RBCs.
Limited data suggest that autologous hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. In a parallel-group randomized trial involving 45 adult patients who had refractory Crohn disease not amenable to surgery and impaired quality of life despite treatment with 3 or more immunosuppressive biologic agents and corticosteroids, Hawkey and colleagues found that HCST was no different from conventional therapy in achieving sustained disease remission at 1 year and was associated with significant toxicity.
Highlights. JAMA. 2015;314(23):2469–2471. doi:10.1001/jama.2014.12145
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