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Editorial
June 21, 2016

Clinical Practice Guidelines for Colorectal Cancer Screening: New Recommendations and New Challenges

Author Affiliations
  • 1Lineberger Comprehensive Cancer Center, Departments of Medicine (Gastroenterology and Hepatology) and Epidemiology, University of North Carolina at Chapel Hill
  • 2The Patient-Centered Outcomes Research Institute, Washington, DC
  • 3Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
JAMA. 2016;315(23):2529-2531. doi:10.1001/jama.2016.7990

For 32 years, the United States Preventive Services Task Force (USPSTF) has served the nation with analyses that are scientific, transparent, and untainted by conflict of interest and political influence. While the task force has been the acknowledged leader in developing preventive services guidelines, its work environment is evolving under intense scrutiny from many powerful interests, including patients, clinicians, insurers, and politicians. The Affordable Care Act of 2010 added to the challenges by mandating private insurance coverage for preventive services that the USPSTF strongly recommends (that is, preventive services that receive a grade of A or B).1,2

This issue of JAMA contains the USPSTF Recommendation Statement for colorectal cancer screening,3 along with an updated systematic Evidence Review4 and report of the microsimulation modeling study5 that were used to inform the screening recommendations. This editorial summarizes the clinical implications of the colorectal cancer screening recommendations, provides historical background information, and shows how the adoption of a shared decision-making paradigm could herald a new era in cancer screening guidelines.

The 2016 guideline strongly recommends screening for colorectal cancer (A recommendation). It lists 7 different screening strategies, stating that “the screening tests are not presented in any preferred or ranked order,” implying that the task force considers them to be equivalent. However, the task force presents evidence that some strategies are better than others when tested in representative populations. Four strategies result in essentially the same life expectancy gains and consumption of health care resources: colonoscopy, fecal immunochemical testing (FIT) for occult blood, sigmoidoscopy plus FIT, and computed tomography (CT) colonography. The task force lists the FIT-DNA test (multitargeted stool DNA test) but states that it is less efficient. Finally, the task force lists 2 strategies (guaiac-based fecal occult blood testing [gFOBT] and sigmoidoscopy alone) but cites evidence suggesting that they, although effective, are inferior to the other listed strategies.

The USPSTF appears to be saying that some tests are better than others, but then does not specify a preference. How can tests differ and yet be the same in the eyes of the task force? In the Recommendation Statement, the task force states a principle that may explain this paradox: “the best screening test is the one that gets performed.” A test can rank low when tested on a representative population but still be better aligned with an individual patient’s preferences and, therefore, be most likely to get done. Thus, to choose among the screening strategies, the USPSTF recommends shared decision making, a process in which physician and patient share information and reach a consensus about what screening test is best for the patient. In shared decision making, the choices do not necessarily have similar outcomes or equivalent efficiency. For the physician, sharing information means providing access to a description of the benefits and harms of the alternatives. For patients, this means describing how they value the strategies and their potential outcomes or declaring their willingness to complete the screening process. To be an equal partner in this conversation, patients must learn about the strategies and their consequences. The physician could describe them or send the patient home with a decision aid to review in advance of a subsequent conversation about screening. This embrace of shared decision making for choosing a screening test is a pivotal step forward for the task force.

It is possible to reconstruct some of the steps along the pathway to shared decision making for colorectal cancer screening. In 2008, the task force issued a screening guideline that stated “The USPSTF recommends screening for colorectal cancer using fecal occult blood testing, sigmoidoscopy, or colonoscopy in adults, beginning at age 50 years and continuing until age 75 years.”6 In October 2015, as required in the development of updated USPSTF reports, the task force posted the draft version of the new colorectal cancer screening recommendations for public comment.7 The 2015 draft recommendation statement gave an A grade to colorectal cancer screening, indicating that “The USPSTF recommends screening for colorectal cancer starting at age 50 years and continuing until age 75 years. The risks and benefits of different screening methods vary.”7 The draft recommendation statement also listed 3 options for screening, including colonoscopy, sigmoidoscopy plus an annual FIT for occult blood, and annual FIT alone.7 The decision modeling analysis8 requested by the USPSTF estimated that these 3 tests provided roughly the same number of life-years gained vs no screening and equivalent resource consumption (measured as the lifetime number of colonoscopies needed, including for screening and diagnosis).

The draft recommendation also included a new category, termed “alternative tests,” in which 2 other tests, CT colonography and FIT-DNA, were listed but not explicitly recommended,7 even though the estimated life-years gained and resources used with these tests were only modestly different than the 3 recommended strategies.8 As with other USPSTF reports, the draft version of the recommendation statement generated public comment, including, as the task force clearly acknowledges,3 many comments expressing concern that the terms “recommended” and “alternative” lacked clarity.

In the final Recommendation Statement3 published in this issue of JAMA, the main conclusion is as follows: “The USPSTF recommends screening for colorectal cancer starting at age 50 years and continuing until age 75 years. (A recommendation).” The Recommendation Statement also includes a section on Clinical Considerations that lists 7 strategies: the original 3 strategies, the 2 previously termed “alternative,” and 2 others (gFOBT and sigmoidoscopy without a stool-based test).

Clinicians and patients will understand the importance of screening and making an informed choice among the 7 strategies. For private insurers, the A recommendation mandates coverage for colorectal cancer screening, but the lack of a statement indicating that the task force recommends specific tests or strategies leaves some ambiguity about whether private insurance must cover each of the specific tests.

Ideally, the USPSTF would have based its recommendations for specific colorectal cancer screening tests on randomized trials, the strongest kind of evidence about the effect of screening on the length and quality of life. However, the only strategies based on randomized trial findings are sigmoidoscopy plus annual FIT, sigmoidoscopy alone, and gFOBT. In contrast, the source of the main evidence for CT colonography, FIT alone, and FIT-DNA is cross-sectional: studies that measure test sensitivity and specificity at a point in time but cannot measure the effects on life expectancy or resource utilization. Decision modeling can project screening test results forward to their estimated effects on life expectancy and colonoscopies needed. The USPSTF has been a leader in using decision modeling to translate evidence of screening test accuracy into health effects.

In both 2008 and the draft recommendations in 2015, the short list of acceptable screening strategies was derived by using a modeling concept called “the efficient frontier.”8,9 The frontier is a line connecting the strategies with the highest expected gain in life-years per colonoscopy performed; these are called efficient strategies. Strategies that were below the frontier but with life-years gained at least 98% of that of the efficient frontier were near efficient and all others were inefficient. In the final recommendation, the USPSTF list of 7 acceptable strategies included 4 that were efficient and 1 near efficient (FIT-DNA), as well as 2 that were inefficient.

The process the task force used to decide which screening strategies are acceptable deserves scrutiny because the recommendation affects everyone: patients, clinicians, payers, policy makers, and test manufacturers. The accompanying article on decision modeling5 describes the USPSTF process in detail. The openness of that description invites questions. For example, how did the task force decide on the minimum effect of screening (measured in life-years gained) to qualify as an acceptable screening strategy? Based on the exclusion of 2 near-efficient strategies, an acceptable strategy had to be on—or very close to—the efficient frontier in 20089 and at the time of the 2015 draft recommendations.8 In the final recommendations, FIT-DNA, a near-efficient strategy, was included in the list of acceptable strategies despite performing below the efficient frontier, as were gFOBT and sigmoidoscopy alone.5 In its current Recommendation Statement, the USPSTF now acknowledges, appropriately, the many other “moving parts” that affect the clinical outcomes of screening programs in practice. For example, colonoscopy quality may vary widely10,11 as may the performance and accuracy of imaging procedures and stool-based screening tests. The task force appears to believe that the most important of these moving parts is the likelihood that the patient will actually undergo screening with a test that has been deemed “acceptable.” The predictors of submitting to different colorectal cancer screening procedures are not known, so the task force could not expect the modeling teams to list the predictors of success for each screening procedure. Instead, they provide population-based information about the consequences of the strategies that, together with the patient’s preferences, can inform a shared decision.

The USPSTF should be applauded for taking a global approach to a screening recommendation. The unique feature of the 2016 recommendations is that a goal—to increase screening rates—is driving the implementation strategy, which is to use shared decision making about an unusually broad range of screening options. Stakeholders—patients, physicians, health plans, and insurers—will want to know if the task force plans to take this approach for future screening topics. When the task force does recommend shared decision making, it would be helpful to develop a patient-friendly table that displays all of the evidence about all of the acceptable strategies.

Guidelines creation—going from evidence to policy—is one of the most important and demanding duties of our profession. Preventive services recommendations are especially challenging for reasons involving clinical, scientific, and political considerations. Fortunately, the federal government has invested in its preventive services program since 1984, and the program has steadily increased in stature and in scientific leadership. The colorectal cancer screening guideline is a prime example of strong leadership. However, as the USPSTF has evolved and as the ramifications of its recommendations have become increasingly important, some difficult challenges have arisen. Ensuring that the USPSTF receives the support to meet these challenges and to continue to fulfill its critical mission is more important now than ever before.

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Article Information

Corresponding Author: David F. Ransohoff, MD, Departments of Medicine and Epidemiology, University of North Carolina, CB #7080, Chapel Hill, NC 27599-7080 (ransohof@med.unc.edu).

Published Online: June 15, 2016. doi:10.1001/jama.2016.7990.

Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Ransohoff was a paid consultant to Exact Sciences from 1998 to 2002. In 2004 and 2014, he was an author of 2 validation studies of CRC screening using stool DNA, which were funded by Exact Sciences, and in 2014 he was an author of a validation study of CRC screening using blood DNA, funded by Epigenomics. He reports that since 2002, he has had no fees, equity, salary support, or other income from Exact Sciences, Epigenomics, or any maker of a CRC-related diagnostic product. He also reports receiving travel reimbursement for investigators’ meetings from Exact Sciences and Epigenomics. Dr Sox chaired the USPSTF from 1991 through 1996 and continued as a member from 1998 to 2001. He was a member of a medical advisory board of the Epigenomics Corporation from 2011 to 2014. He reports receiving no fees, equity, salary support, or any other income for this service. No other disclosures are reported.

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    1 Comment for this article
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    Plasma methylated septin 9: may be an early colorectal cancer screening marker but never a first option
    Professor( Dr.)Pranab Kumar Bhattacharya; Miss Upasana Bhattacharya ; Dr Sumana Mukherjee- Associate Professor Pathology STM kolkata ; Rupak Bhattacharya BSC(cal Univ) MSc(JU) , Ritwick Bhattacharya B.Com( Cal Univ) | Professor of Pathology Murshidabad District Medical College Behrampore Court Murshidabad West Bengal India and Calcutta school of Tropical Medicine CR Avenue Kolkata -700073 West Bengal India

    Colorectal cancer (CRC) is the 3rd leading cause of new cancer cases in the United States in 2014[1]. The prevention of CRC should aim at early most detection. However, 60%-70% of patients are found at middle or late stage CRC when they are first-time diagnosed, leading to the high mortality in CRC [2]. The low detection rate of early stage CRC is mainly due to late onset of clinical symptoms and lack of effective early detection methods. Therefore, regular screening with effective early detection methods is needed to prolong patients’ lives and reduce mortality.
    Four types of test are currently available
    for CRC detection or screening, including faecal-based occult blood test (FOBT or FIT),tumour marker blood test, combined faecal DNA and FIT test, and imaging test (colonoscopy). The specificity or sensitivity for FOBT or FIT is not sufficient, and compliance is low due to the inconvenience in sampling and the interference of the test results by many factors . The serum-based non-invasive tumour markers used in clinical laboratories, including carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), are not appropriate for screening due to their low sensitivity and the lack of CRC specificity, especially for early stage CRC [3-5 ]. More recently, the FDA-approved faecal DNA test (Cologuard, Exact Sciences, Madison, WI, USA) exhibited high sensitivity in detecting CRC (87 %) and adenomas ≥ 1 cm (82%) [6]. The test includes mutation detection, methylation detection and FIT. However, the price of the test is much higher than that of the SEPT9 or FIT test, due to the combination of multiple indicators. Colonoscopy is still now regarded as the gold standard for CRC diagnosis when combined with pathological examinations. However, its compliance is low due to its high costs, inconvenient preparation process, invasive procedure, and multiple complications. Septin-9 is a protein that in humans is encoded by the SEPT9 gene. SEPT9 has been shown to interact with SEPT2 [7] and SEPT7[7 ]Along with AHNAK, eIF4E and S100A11, SEPT9 was shown to be essential for pseudopod protrusion, tumor cell migration and invasion. The v2 region of the SEPT9 promoter had been shown to be methylated in colorectal cancer tissue compared with normal colonic mucosa Using highly sensitive real time PCR assays, methylated SEPT9 can be detected in the blood of colorectal cancer patients. This alternate methylation pattern in cancer samples is suggestive of an aberrant activation or repression of the gene compared to normal tissue samples
    The SEPT9 gene methylation assay, a blood-based test used specifically for CRC detection and screening, was developed and used clinically for the above purposes. Septins are a group of scaffolding proteins that provide structural support during cell division Individual septins exist in stable six-to eight-subunit core heteromers, and the octamer contains two molecules of each of SEPT2, SEPT6, SEPT7, and SEPT9 subunits [7]. It was suggested that SEPT9 occupies a terminal position in the complex and plays a key role in subunit polymerization and the whole octamer stablization [7]. It is also critical for the final separation of daughter cells during cytokinesis . Therefore, cytokinesis may be seriously affected if abnormal SEPT9 or no SEPT9 is expressed, and this could be a key factor in CRC carcinogenesis when the promoter region of the SEPT9 gene is hypermethylated and the transcription is compromised The SEPT9 gene methylation assay aim at detecting the aberrant methylation at the promoter region of the SEPT9 gene DNA released from CRC cells into the peripheral blood. In brief, the promoter region of the SEPT9 gene is hyper methylated and DNA of the gene is released into the peripheral circulating blood from necrotic and apoptotic cancer cells during CRC carcinogenesis, therefore, the risk of CRC can be determined by detecting the degree of DNA methylation of the specific promoter region of the SEPT9 gene in the peripheral blood. It was shown recently that major changes in the methylation pattern of SEPT9_V2 transcriptin colon adenoma and cancer tissues is confined to only one of the CpG islands, the CGI3. Due to the presence of trace amount of methylated SEPT9 DNA in the peripheral blood, the detection of DNA methylation must be sensitive enough to distinguish tiny amount of methylated DNA from much higher concentration of background un-methylated genome DNA. This requires accurate design of methylation probes and optimization of the whole PCR reaction system. Since the amount of methylated SEPT9 DNA from 10 ml whole blood sample is always as low as several genome copies, multiple PCR reactions has to be performed to enhance the detection sensitivity. The current commercialized SEPT9 assay (e.g., Epi proColon2.0) performs three PCR reactions and can detect as low as 2genome copies of methylated SEPT9 per millilitre of plasma in the background of 100 ng/ml un methylated genome DNA
    Inspite of big variation in sensitivity of SEP9 from 48.2% to 95.6% observed among the assays with different algorithm, the specificity (80%-100%) remained high regardless of the variation in sensitivity In CRC .
    Testing to detect methylated SEPT9 is not how ever indicated as a first option for colorectal cancer screening or colorectal adenoma .[8 ] It is similar in specificity and sensitivity to the stool guaiac test or fecal immune tests, and those tests should be used in preference.[8 ] In cases when the physician aggressively has recommended a colonoscopy and the patient has declined that and these other tests, then this test has advantages over patients having no screening at all

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    3] Wild N , Andres H, Rollinger W, Krause F, Dilba P, et al. (2010) A combination of serum markers for the early detection of colorectal cancer. Clin Cancer Res 16: 6111-6121.

    4] J.S. Chen, K.T. Chen, W.C. Fan, Yu JS, Chang YS, et al. (2010) Combined analysis of survivin autoantibody and carcinoembryonic antigenbiomarkers for improved detection of colorectal cancer. Clin ChemLab Med 48: 719-725

    5] Yu H, Son GM, Joh YG (2013) The clinical significance of pre operative serum levels of carbohydrate antigen 19-9 in colorectal cancer. J Korean Surg Soc 84: 231-237..

    6] Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, et al. (2012)Next-generation stool DNA test accurately detects colorectal cancer and large adenomas. Gastroenterology 142: 248-256.
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    7] Osaka M, Rowley JD, Zeleznik-Le NJ (May 1999). \"MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)\". Proceedings of the National Academy of Sciences of the United States of America 96 (11): 6428–33. doi:10.1073/pnas.96.11.6428. PMC 26898. PMID 10339604.

    8]American Society for Clinical Pathology, \"Five Things Physicians and Patients Should Question\", Choosing Wisely: an initiative of the ABIM Foundation (American Society for Clinical Pathology), retrieved August 1, 2013, which cites

    9] Potter NT1, Hurban P2, White MN3, Whitlock KD3, Lofton-Day CE4,et al. (2014) Validation of a real-time PCR-based qualitative assay forthe detection of methylated SEPT9 DNA in human plasma. Clin Chem60: 1183-1191.

    CONFLICT OF INTEREST: None Reported
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