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Statin drugs may help to stabilize coronary lesions. Berwanger and colleagues for the SECURE-PCI Investigators randomized 4191 patients with acute coronary syndrome and found that loading doses of atorvastatin before and after percutaneous coronary intervention did not reduce the rate of major adverse cardiovascular events. In an Editorial, Nicholls and Psaltis discuss the overall benefits of lipid-lowering drugs for patients with acute coronary syndrome.
The association of lower socioeconomic status and adverse health outcomes may be exacerbated by the stress of a sudden loss of wealth. In a nationally representative prospective cohort study of US adults aged 51 to 61 years, Pool and colleagues found that loss of wealth over 2 years was associated with an increased risk for all-cause mortality. In an Editorial, Garber suggests that wealth shock has implications for health behaviors and patient well-being, irrespective of whether it is a direct cause of mortality or a marker of underlying health risks.
When combusted, solid fuels such as wood and charcoal emit airborne particulate matter. In a prospective cohort study of 271 217 adults from rural China, Yu and colleagues found that associations of solid fuel use with cardiovascular and all-cause mortality were lower for those who had previously switched to clean fuels or used cookstoves with ventilation.
Infants exposed to opioids in utero who experience withdrawal symptoms after birth are typically treated with decreasing doses of replacement opioids. Wachman and colleagues review the clinical management of neonatal abstinence syndrome.
In this JAMA Clinical Guidelines Synopsis of a 2018 guideline developed by the Endocrine Society with cosponsorship from the European Society of Endocrinology, Sargis and Davis discuss the clinical management of men with hypogonadism.
This JAMA Diagnostic Test Interpretation article by Stein and colleagues presents a 20-year-old woman with a positive direct antiglobulin test result who had responded poorly to treatment for community-acquired pneumonia. How would you interpret these results?
Highlights. JAMA. 2018;319(13):1293–1295. doi:10.1001/jama.2017.12306
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