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In This Issue of JAMA
April 10, 2018


JAMA. 2018;319(14):1415-1417. doi:10.1001/jama.2017.12317

Variation in the prevalence of risk factors can account for differences in health outcomes. The US Burden of Disease Collaborators analyzed published studies and data sources by age, sex, geography, and year and found that differences in health outcomes were attributable to substance use disorders, high body mass index, diet, and high fasting plasma glucose. In an Editorial, Koh and Parekh suggest that greater investment in public health and social programs could yield healthier behaviors and more supportive environments.


Author Audio Interview and CME

Stepwise escalation in therapy is recommended for patients with persistent asthma despite daily use of inhaled corticosteroids. Sobieraj and colleagues conducted a systematic review and meta-analysis of 15 randomized clinical trials in 7122 patients with uncontrolled, persistent asthma and concluded that adding a long-acting muscarinic antagonist to inhaled corticosteroids was associated with a lower risk of asthma exacerbations. In an Editorial, Krishnan and Au call for an update to current guidelines on pharmacotherapies for persistent asthma.