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In This Issue of JAMA
June 12, 2018


JAMA. 2018;319(22):2249-2251. doi:10.1001/jama.2017.12405

Negative pressure wound therapy promotes wound drainage and may increase the formation of granulation tissue. In a randomized clinical trial of negative pressure wound therapy vs standard wound dressings in 460 patients with open fractures of the lower limb, Costa and colleagues for the UK WOLFF Collaboration found no difference in self-rated disability at 12 months after injury.

Depression is an adverse event associated with many prescription medications. In a study of 26 192 US adults interviewed for the National Health and Nutrition Examination Survey, Qato and colleagues found that the likelihood of depression was greatest in patients taking 3 or more medications listed as having depression as a possible adverse effect.


Pentraxin 2 inhibits the production of transforming growth factor-β1, a key mediator of pulmonary fibrosis. Raghu and colleagues randomized 117 patients with idiopathic pulmonary fibrosis and found that treatment with recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks. In an Editorial, Gibson and Kass suggest that future trials of therapies for idiopathic pulmonary fibrosis should address exercise capacity as well as change in pulmonary function.


Clinical Review & Education

Evidence supports the Framingham Risk Score and the Pooled Cohort Equations for assessing the risk of cardiovascular disease. This US Preventive Services Task Force statement recommends against screening with electrocardiography in asymptomatic adults at low risk of cardiovascular events. In an Editorial, Myerburg suggests that more research is needed on the efficacy of electrocardiography screening for special populations such as athletes.

Editorial, Related Article, and JAMA Patient Page

Author Audio Interview and CME

In a review of 16 studies with 77 140 participants, Jonas and colleagues concluded that screening with exercise electrocardiography was not associated with better health outcomes.

Editorial, Related Article, and JAMA Patient Page

In patients with symptomatic peripheral artery disease, ischemic events are associated with increased platelet and thrombotic activity. This JAMA Insights article by Hess and Hiatt recommends treatment categories for patients with peripheral artery disease.