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Research Letter
July 3, 2018

Maternal Type 1 Diabetes and Risk of Autism in Offspring

Author Affiliations
  • 1Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
  • 2Division of Endocrinology and Diabetes, University of Southern California Keck School of Medicine, Los Angeles
  • 3Department of Obstetrics and Gynecology, Kaiser Permanente Southern California, Pasadena
JAMA. 2018;320(1):89-91. doi:10.1001/jama.2018.7614

Maternal preexisting type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) diagnosed by 26 weeks’ gestation have been associated with increased risk of autism spectrum disorder (ASD) in offspring.1 However, little is known about ASD risk associated with maternal preexisting type 1 diabetes (T1D). We extend previous observations by examining the risk of ASD in offspring associated with maternal T1D, T2D, and GDM.

This retrospective cohort study included singleton children born at 28 to 44 weeks’ gestation in Kaiser Permanente Southern California (KPSC) hospitals from January 1, 1995, through December 31, 2012. Children were tracked through electronic health records from age 1 year until the first date of the following: clinical diagnosis of ASD, last date of continuous KPSC membership, death, or study end date (December 31, 2017). The KPSC institutional review board approved this study and provided waiver of participant consent.