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Treatment guidelines do not recommend a specific diet for children with nonalcoholic fatty liver disease. In a randomized trial that enrolled 40 male adolescents aged 11 to 16 years with histologically diagnosed nonalcoholic fatty liver disease, Schwimmer and colleagues found that a diet low in free sugar content decreased hepatic steatosis.
In children with sickle cell disease and high transcranial Doppler (TCD) velocities, transfusion therapy reduces the risk of stroke but is associated with complications such as alloimmunization and iron overload. Bernaudin and colleagues for the DREPAGREFFE Trial Investigators studied 67 children with sickle cell disease who required chronic transfusions for persistently elevated TCD velocities and found that matched-sibling donor hematopoietic stem cell transplantation was associated with lower TCD velocities compared with standard care. In an Editorial, Kwiatkowski suggests that future trials should evaluate the efficacy of transplantation using alternative sources of stem cells for children who lack a matched sibling donor.
Highlights. JAMA. 2019;321(3):217–219. doi:10.1001/jama.2018.15157
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