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April 23/30, 2019

Numerical Errors and Addition of a Sentence

JAMA. 2019;321(16):1636. doi:10.1001/jama.2019.3497

In the Original Investigation entitled “Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease,”1 published in the February 26, 2019, issue of JAMA, there were numerical errors. In the Results section, Estimated Potential Clinical Effectiveness subsection, second paragraph, the second sentence should be “For every 10 000 patients genotyped, 996 would test positive for a TPMT variant and need to receive an alternative therapy to prevent TIM in 81 patients (95% CI, 43-133 patients).” Immediately after, the following should be added: “Genotyping 10 000 patients for TPMT would prevent 81 cases of TIM, which is 123 genotyped for every case prevented.” This article was corrected online.

Walker  GJ, Harrison  JW, Heap  GA,  et al; IBD Pharmacogenetics Study Group.  Association of genetic variants in NUDT15 with thiopurine-induced myelosuppression in patients with inflammatory bowel disease.  JAMA. 2019;321(8):773-785. doi:10.1001/jama.2019.0709PubMedGoogle ScholarCrossref