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See the Figure for a more detailed summary of the recommendation for clinicians.

Figure.
Clinician Summary for Screening for Asymptomatic Bacteriuria in Adults
Clinician Summary for Screening for Asymptomatic Bacteriuria in Adults

CFU indicates colony-forming units; USPSTF, US Preventive Services Task Force.

Table.  
Summary of USPSTF Rationale
Summary of USPSTF Rationale
1.
Foxman  B.  Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden.  Infect Dis Clin North Am. 2014;28(1):1-13. doi:10.1016/j.idc.2013.09.003PubMedGoogle ScholarCrossref
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Henderson  J, Webber  E, Bean  S.  Screening for Asymptomatic Bacteriuria in Adults: An Updated Systematic Review for the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality; 2019.
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Hooton  TM, Scholes  D, Stapleton  AE,  et al.  A prospective study of asymptomatic bacteriuria in sexually active young women.  N Engl J Med. 2000;343(14):992-997. doi:10.1056/NEJM200010053431402PubMedGoogle ScholarCrossref
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Ferroni  M, Taylor  AK.  Asymptomatic bacteriuria in noncatheterized adults.  Urol Clin North Am. 2015;42(4):537-545. doi:10.1016/j.ucl.2015.07.003PubMedGoogle ScholarCrossref
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Schnarr  J, Smaill  F.  Asymptomatic bacteriuria and symptomatic urinary tract infections in pregnancy.  Eur J Clin Invest. 2008;38(suppl 2):50-57. doi:10.1111/j.1365-2362.2008.02009.xPubMedGoogle ScholarCrossref
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Nicolle  LE, Bradley  S, Colgan  R, Rice  JC, Schaeffer  A, Hooton  TM; Infectious Diseases Society of America; American Society of Nephrology; American Geriatric Society.  Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults.  Clin Infect Dis. 2005;40(5):643-654. doi:10.1086/427507PubMedGoogle ScholarCrossref
7.
Macejko  AM, Schaeffer  AJ.  Asymptomatic bacteriuria and symptomatic urinary tract infections during pregnancy.  Urol Clin North Am. 2007;34(1):35-42. doi:10.1016/j.ucl.2006.10.010PubMedGoogle ScholarCrossref
8.
Hill  JB, Sheffield  JS, McIntire  DD, Wendel  GD  Jr.  Acute pyelonephritis in pregnancy.  Obstet Gynecol. 2005;105(1):18-23. doi:10.1097/01.AOG.0000149154.96285.a0PubMedGoogle ScholarCrossref
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Wing  DA, Fassett  MJ, Getahun  D.  Acute pyelonephritis in pregnancy: an 18-year retrospective analysis.  Am J Obstet Gynecol. 2014;210(3):219.e1-219.e6. doi:10.1016/j.ajog.2013.10.006PubMedGoogle ScholarCrossref
10.
Dull  RB, Friedman  SK, Risoldi  ZM, Rice  EC, Starlin  RC, Destache  CJ.  Antimicrobial treatment of asymptomatic bacteriuria in noncatheterized adults: a systematic review.  Pharmacotherapy. 2014;34(9):941-960. doi:10.1002/phar.1437PubMedGoogle ScholarCrossref
11.
Glaser  AP, Schaeffer  AJ.  Urinary tract infection and bacteriuria in pregnancy.  Urol Clin North Am. 2015;42(4):547-560. doi:10.1016/j.ucl.2015.05.004PubMedGoogle ScholarCrossref
12.
Juthani-Mehta  M.  Asymptomatic bacteriuria and urinary tract infection in older adults.  Clin Geriatr Med. 2007;23(3):585-594. doi:10.1016/j.cger.2007.03.001PubMedGoogle ScholarCrossref
13.
Verani  J, McGee  L, Schrag  S.  Prevention of Preinatal Group B Streptococcal Disease. Atlanta, GA: Centers for Disease Control and Prevention; 2010.
14.
US Preventive Services Task Force.  Guide to Clinical Preventive Services: Guide to Clinical Preventive Services: Report of the U.S. Preventive Services Task Force. Baltimore, MD: Agency for Healthcare Research and Quality; 1996.
15.
US Preventive Services Task Force.  Screening for Asymptomatic Bacteriuria: Recommendation Statement. Rockville, MD: Agency for Healthcare Research and Quality; 2004.
16.
U.S. Preventive Services Task Force.  Screening for asymptomatic bacteriuria in adults: U.S. Preventive Services Task Force reaffirmation recommendation statement.  Ann Intern Med. 2008;149(1):43-47. doi:10.7326/0003-4819-149-1-200807010-00009PubMedGoogle ScholarCrossref
17.
Henderson  JT, Webber  EM, Bean  SI.  Screening for asymptomatic bacteriuria in adults: updated evidence report and systematic review for the US Preventive Services Task Force  [published September 24, 2019]. JAMA. doi:10.1001/jama.2019.10060
18.
Uncu  Y, Uncu  G, Esmer  A, Bilgel  N.  Should asymptomatic bacteriuria be screened in pregnancy?  Clin Exp Obstet Gynecol. 2002;29(4):281-285.PubMedGoogle Scholar
19.
Gratacós  E, Torres  PJ, Vila  J, Alonso  PL, Cararach  V.  Screening and treatment of asymptomatic bacteriuria in pregnancy prevent pyelonephritis.  J Infect Dis. 1994;169(6):1390-1392. doi:10.1093/infdis/169.6.1390PubMedGoogle ScholarCrossref
20.
Wren  BG.  Subclinical renal infection and prematurity.  Med J Aust. 1969;2(12):596-600.PubMedGoogle ScholarCrossref
21.
Williams  GL, Campbell  H, Davies  KJ.  Urinary concentrating ability in women with asymptomatic bacteriuria in pregnancy.  Br Med J. 1969;3(5664):212-215. doi:10.1136/bmj.3.5664.212PubMedGoogle ScholarCrossref
22.
Furness  ET, McDonald  PJ, Beasley  NV.  Urinary antiseptics in asymptomatic bacteriuria of pregnancy.  N Z Med J. 1975;81(539):417-419.PubMedGoogle Scholar
23.
Elder  HA, Santamarina  BA, Smith  S, Kass  EH.  The natural history of asymptomatic bacteriuria during pregnancy: the effect of tetracycline on the clinical course and the outcome of pregnancy.  Am J Obstet Gynecol. 1971;111(3):441-462. doi:10.1016/0002-9378(71)90793-9PubMedGoogle ScholarCrossref
24.
Little  PJ.  The incidence of urinary infection in 5000 pregnant women.  Lancet. 1966;2(7470):925-928. doi:10.1016/S0140-6736(66)90534-4PubMedGoogle ScholarCrossref
25.
Foley  ME, Farquharson  R, Stronge  JM.  Is screening for bacteriuria in pregnancy worthwhile?  Br Med J (Clin Res Ed). 1987;295(6592):270. doi:10.1136/bmj.295.6592.270PubMedGoogle ScholarCrossref
26.
Pathak  UN, Tang  K, Williams  LL, Stuart  KL.  Bacteriuria of pregnancy: results of treatment.  J Infect Dis. 1969;120(1):91-103. doi:10.1093/infdis/120.1.91PubMedGoogle ScholarCrossref
27.
Kincaid-Smith  P, Bullen  M.  Bacteriuria in pregnancy.  Lancet. 1965;1(7382):395-399. doi:10.1016/S0140-6736(65)90001-2PubMedGoogle ScholarCrossref
28.
Savage  WE, Hajj  SN, Kass  EH.  Demographic and prognostic characteristics of bacteriuria in pregnancy.  Medicine (Baltimore). 1967;46(5):385-407. doi:10.1097/00005792-196709000-00002PubMedGoogle ScholarCrossref
29.
Gold  EM, Traub  FB, Daichman  I, Terris  M.  Asymptomatic bacteriuria during pregnancy.  Obstet Gynecol. 1966;27(2):206-209.PubMedGoogle Scholar
30.
Brumfitt  W.  The effects of bacteriuria in pregnancy on maternal and fetal health.  Kidney Int Suppl. 1975;4:S113-S119.PubMedGoogle Scholar
31.
Kazemier  BM, Koningstein  FN, Schneeberger  C,  et al.  Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial.  Lancet Infect Dis. 2015;15(11):1324-1333. doi:10.1016/S1473-3099(15)00070-5PubMedGoogle ScholarCrossref
32.
Giamarellou  H, Dontas  A, Zorbas  P, Staszewska-Pistoni  M, Xirouchaki  E, Petrikkos  G.  Asymptomatic bacteriuria in freely voiding elderly subjects: long-term continuous vs pulse treatment with ofloxacin.  Clin Drug Investig. 1998;15(3):187-195. doi:10.2165/00044011-199815030-00003PubMedGoogle ScholarCrossref
33.
Abrutyn  E, Mossey  J, Berlin  JA,  et al.  Does asymptomatic bacteriuria predict mortality and does antimicrobial treatment reduce mortality in elderly ambulatory women?  [published correction appears in Ann Intern Med. 1994;121(11):901].  Ann Intern Med. 1994;120(10):827-833. doi:10.7326/0003-4819-120-10-199405150-00003PubMedGoogle ScholarCrossref
34.
Asscher  AW, Sussman  M, Waters  WE,  et al.  The clinical significance of asymptomatic bacteriuria in the nonpregnant woman.  J Infect Dis. 1969;120(1):17-26. doi:10.1093/infdis/120.1.17PubMedGoogle ScholarCrossref
35.
Boscia  JA, Kobasa  WD, Knight  RA, Abrutyn  E, Levison  ME, Kaye  D.  Therapy vs no therapy for bacteriuria in elderly ambulatory nonhospitalized women.  JAMA. 1987;257(8):1067-1071. doi:10.1001/jama.1987.03390080057030PubMedGoogle ScholarCrossref
36.
Harding  GK, Zhanel  GG, Nicolle  LE, Cheang  M; Manitoba Diabetes Urinary Tract Infection Study Group.  Antimicrobial treatment in diabetic women with asymptomatic bacteriuria.  N Engl J Med. 2002;347(20):1576-1583. doi:10.1056/NEJMoa021042PubMedGoogle ScholarCrossref
37.
Farkash  E, Weintraub  AY, Sergienko  R, Wiznitzer  A, Zlotnik  A, Sheiner  E.  Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and outcomes.  Eur J Obstet Gynecol Reprod Biol. 2012;162(1):24-27. doi:10.1016/j.ejogrb.2012.01.024PubMedGoogle ScholarCrossref
38.
Smaill  FM, Vazquez  JC.  Antibiotics for asymptomatic bacteriuria in pregnancy.  Cochrane Database Syst Rev. 2015;(8):CD000490.PubMedGoogle Scholar
39.
U.S. Preventive Services Task Force. Procedure Manual. https://www.uspreventiveservicestaskforce.org/Page/Name/procedure-manual. Published 2018. Accessed June 28, 2019.
40.
Nicolle  LE, Gupta  K, Bradley  SF,  et al.  Clinical practice guideline for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America  [published online March 21, 2019].  Clin Infect Dis. doi:10.1093/cid/ciy1121Google Scholar
41.
Canadian Task Force on Preventive Health Care (CTFPHC). Asymptomatic Bacteriuria in Pregnancy (2018). CTFPHC website. https://canadiantaskforce.ca/guidelines/published-guidelines/asymptomatic-bacteriuria/. Published 2018. Accessed August 19, 2019.
42.
American Academy of Family Physicians (AAFP). Summary of Recommendations for Clinical Preventive Services. AAFP website. https://www.aafp.org/dam/AAFP/documents/patient_care/clinical_recommendations/cps-recommendations.pdf. Published 2017. Accessed August 19, 2019.
43.
National Institute for Health and Care Excellence (NICE). Urinary tract infection (lower): antimicrobial prescribing. NICE website. https://www.nice.org.uk/guidance/ng109. Published 2018. Accessed August 19, 2019.
44.
American Academy of Pediatrics and American College of Obstetricians and Gynecologists.  Guidelines for Prenatal Care. 7th ed. Itasca, IL: American Academy of Pediatrics; 2012.
45.
American College of Obstetricians and Gynecologists (ACOG).  ACOG Practice Bulletin No. 91: treatment of urinary tract infections in nonpregnant women.  Obstet Gynecol. 2008;111:785-794. doi:10.1097/AOG.0b013e318169f6efPubMedGoogle ScholarCrossref
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US Preventive Services Task Force
Recommendation Statement
September 24, 2019

Screening for Asymptomatic Bacteriuria in Adults: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force
JAMA. 2019;322(12):1188-1194. doi:10.1001/jama.2019.13069
Abstract

Importance  Among the general adult population, women (across all ages) have the highest prevalence of asymptomatic bacteriuria, although rates increase with age among both men and women. Asymptomatic bacteriuria is present in an estimated 1% to 6% of premenopausal women and an estimated 2% to 10% of pregnant women and is associated with pyelonephritis, one of the most common nonobstetric reasons for hospitalization in pregnant women. Among pregnant persons, pyelonephritis is associated with perinatal complications including septicemia, respiratory distress, low birth weight, and spontaneous preterm birth.

Objective  To update its 2008 recommendation, the USPSTF commissioned a review of the evidence on potential benefits and harms of screening for and treatment of asymptomatic bacteriuria in adults, including pregnant persons.

Population  This recommendation applies to community-dwelling adults 18 years and older and pregnant persons of any age without signs and symptoms of a urinary tract infection.

Evidence Assessment  Based on a review of the evidence, the USPSTF concludes with moderate certainty that screening for and treatment of asymptomatic bacteriuria in pregnant persons has moderate net benefit in reducing perinatal complications. There is adequate evidence that pyelonephritis in pregnancy is associated with negative maternal outcomes and that treatment of screen-detected asymptomatic bacteriuria can reduce the incidence of pyelonephritis in pregnant persons. The USPSTF found adequate evidence of harms associated with treatment of asymptomatic bacteriuria (including adverse effects of antibiotic treatment and changes in the microbiome) to be at least small in magnitude. The USPSTF concludes with moderate certainty that screening for and treatment of asymptomatic bacteriuria in nonpregnant adults has no net benefit. The known harms associated with treatment include adverse effects of antibiotic use and changes to the microbiome. Based on these known harms, the USPSTF determined the overall harms to be at least small in this group.

Recommendations  The USPSTF recommends screening pregnant persons for asymptomatic bacteriuria using urine culture. (B recommendation) The USPSTF recommends against screening for asymptomatic bacteriuria in nonpregnant adults. (D recommendation)

Summary of Recommendations
Introduction

Quiz Ref IDAsymptomatic bacteriuria is defined as the presence of bacteria in the urine of a person without signs or symptoms of a urinary tract infection.1 Among the general adult population, women (across all ages) have the highest prevalence of asymptomatic bacteriuria, although rates increase with age among both men and women.2 The reported prevalence of asymptomatic bacteriuria ranges from 1% to 6% among premenopausal women to 22% among women older than 90 years.3,4 Asymptomatic bacteriuria is present in an estimated 2% to 10% of pregnant women.5 The condition is rare in men.4,6

Quiz Ref IDDuring pregnancy, physiologic changes that affect the urinary tract increase the risk of asymptomatic bacteriuria and symptomatic urinary tract infections, including pyelonephritis (a urinary tract infection in which one or both kidneys become infected).7 Pyelonephritis is one of the most common nonobstetric reasons for hospitalization in pregnant women.8 Pyelonephritis is associated with perinatal complications including septicemia, respiratory distress, low birth weight, and spontaneous preterm birth.9

The presence of asymptomatic bacteriuria has not been shown to increase the risk of adverse health outcomes among nonpregnant persons.6,10

USPSTF Assessment of Magnitude of Net Benefit
Pregnant Persons

Quiz Ref IDThe USPSTF concluded with moderate certainty that screening for and treatment of asymptomatic bacteriuria in pregnant persons has moderate net benefit in reducing perinatal complications (Figure and Table; see the eFigure in the Supplement for explanation of USPSTF grades and levels of evidence). There is adequate evidence that pyelonephritis in pregnancy is associated with negative maternal outcomes and that treatment of screen-detected asymptomatic bacteriuria can reduce the incidence of pyelonephritis in pregnant persons. However, evidence shows that the incidence of pyelonephritis among pregnant women with untreated asymptomatic bacteriuria has been low in recent decades, which may reduce the potential benefit from screening asymptomatic bacteriuria. When direct evidence is limited, absent, or restricted to select populations or clinical scenarios, the USPSTF may place conceptual upper or lower bounds on the magnitude of benefit or harms. Therefore, the USPSTF bounds the benefits of screening for asymptomatic bacteriuria in pregnant persons as no greater than moderate.

The USPSTF found inadequate direct evidence on the harms of screening for asymptomatic bacteriuria in pregnant persons, although these harms are thought to be no greater than small in magnitude. The USPSTF found adequate evidence of harms associated with treatment of asymptomatic bacteriuria, including adverse effects of antibiotic treatment. It also considered the potential effects of changes in the microbiome resulting from antibiotic use. Therefore, the USPSTF bounds the overall magnitude of harms of screening for asymptomatic bacteriuria in pregnant persons to be at least small.

Nonpregnant Adults

Quiz Ref IDThe USPSTF concludes with moderate certainty that screening for and treatment of asymptomatic bacteriuria in nonpregnant adults has no net benefit (Table). There is adequate evidence that treatment of screen-detected asymptomatic bacteriuria in nonpregnant adults has no benefit. Based on the harms associated with antibiotic use, the USPSTF found adequate evidence to bound the harms of treatment of screen-detected asymptomatic bacteriuria in nonpregnant adults as at least small.

Practice Considerations
Patient Population Under Consideration

Quiz Ref IDThis recommendation applies to adults 18 years and older and pregnant persons of any age without signs and symptoms of a urinary tract infection (Figure). It does not apply to persons who have chronic medical or urinary tract conditions, such as end-stage renal disease; have indwelling urinary catheters, urinary stents, or spinal cord injuries; are hospitalized; reside in an institution (eg, a nursing home); or who are transplant recipients.

Definition of Asymptomatic Bacteriuria

Asymptomatic bacteriuria occurs when the urinary tract is colonized with significant amounts of pathogenic bacteria, primarily from the gastrointestinal tract, in the absence of symptoms or signs of a urinary tract infection. The most common pathogen is Escherichia coli, although other bacteria such as Klebsiella, Proteus mirabilis, and group B streptococcus can be involved.4,11

Assessment of Risk

The risk of developing asymptomatic bacteriuria varies by age, sex, and pregnancy status.6 Because of the location and length of the female urethra, women are predisposed to infections of the urinary tract, including asymptomatic bacteriuria.5 Physiologic changes in both pregnant and older women increase the risk of asymptomatic bacteriuria and a urinary tract infection.7,11,12 In general, men are at low risk of developing asymptomatic bacteriuria, although rates increase with older age.12 Persons with diabetes are also at increased risk of developing asymptomatic bacteriuria.4,6

Screening Tests

Screening for asymptomatic bacteriuria during pregnancy is done with a urine culture at 12 to 16 weeks of gestation or at the first prenatal visit. Urine culture is currently recommended for screening in pregnancy and is the established method for diagnosis.2 A culture obtained using a midstream, clean-catch urine sample with greater than 100 000 colony-forming units (CFU) per milliliter of a single uropathogen is considered a positive test result.6 Greater than 10 000 CFU/mL of group B streptococcus is an indicator of vaginal colonization and is commonly used as the threshold for treatment of infection in pregnancy.13

Screening Intervals

In general, screening is performed once at the first prenatal visit per clinical guidelines. However, there is little evidence on the optimal timing and frequency of screening for asymptomatic bacteriuria in pregnancy.2

Treatment or Interventions

Pregnant persons with asymptomatic bacteriuria usually receive antibiotic therapy, based on urine culture results and follow-up monitoring. The choice of antibacterial regimen for treatment of asymptomatic bacteriuria during pregnancy is based on safety in pregnancy and patterns of antimicrobial resistance in the particular setting.6,7

Update of Previous USPSTF Recommendation

In this update, the USPSTF continues to recommend screening for asymptomatic bacteriuria in pregnant persons with urine culture and recommends against screening in nonpregnant adults. The USPSTF changed the grade for pregnant persons from an “A” to a “B” based on the reduced applicability of the previous evidence that included outdated antibiotic treatment regimens and newer evidence that shows a significantly lower risk of pyelonephritis than found in previous reviews. In addition, there are newer concerns about antibiotic use, such as antimicrobial resistance and adverse changes to the microbiome (not addressed in current studies), leading to an increase in the magnitude of potential harms. These factors led the USPSTF to reduce assessments of certainty and magnitude of benefit, resulting in the change of grade.

Since 1996, the USPSTF has maintained an “A” recommendation for 1-time screening for asymptomatic bacteriuria with urine culture in pregnant persons between 12 and 16 weeks of gestation. The original 1996 recommendation was reaffirmed in 2004 and again in 2008.14-16 In 1996, the USPSTF found that there was insufficient evidence to recommend for or against screening in older adult women or women with diabetes and, in a separate recommendation, that screening was not recommended in other asymptomatic adults or older adults who reside in an institution.14 In 2004, these recommendations were combined into a single recommendation against screening, which was subsequently reaffirmed in 2008.15,16

Supporting Evidence
Scope of Review

The USPSTF commissioned a systematic evidence review to evaluate the evidence on the potential benefits and harms of screening for and treatment of asymptomatic bacteriuria in community-dwelling adults, including pregnant persons.2,17 This review was used to update the 2008 USPSTF recommendation statement.16

Evidence on Benefits of Screening and Treatment
Pregnant Persons

Two observational cohort studies conducted in Spain and Turkey between 1987 and 199918,19 (n = 5289) examined outcomes in screened and unscreened pregnant women. Both studies included patients screened at the first prenatal visit with urine culture and treated on detection of asymptomatic bacteriuria. In both studies, few cases of pyelonephritis developed in women in either cohort. Only one of the studies reported additional outcomes, including infant birth weight, prematurity, intrauterine death, and intrauterine growth restriction, although the study was not adequately powered to detect differences in these outcomes.2,18

Twelve trials of pregnant women (n = 2377) screened for asymptomatic bacteriuria and randomized to either a treatment or control condition (placebo or no treatment) were included in the review.20-31 Most studies were conducted in hospital-based obstetrics-gynecology clinics. Seven studies reported screening at the first prenatal visit, 2 studies reported the specific gestational age at which screening was performed, and 3 studies did not report the timing of screening.2 All but 2 studies were published in the 1960s or 1970s, with the most recent studies published in 1987 and 2015.25,31 In the older studies, there was sparse reporting on many patient characteristics such as age and race/ethnicity. In addition, treatment regimens for screen-detected asymptomatic bacteriuria varied according to the medication used, timing, duration, and dosage. Antibiotics were used in all studies except 1, although several antibiotics tested in the trials are no longer recommended for treatment of urinary tract infections in pregnancy.2 Rates of pyelonephritis in the control groups were considerably higher in the 10 older studies than in the 2 more recent ones (7% to 36% vs 2.2% and 2.5%, respectively). Lower rates of pyelonephritis in newer studies suggests that the magnitude of benefit from screening may be reduced relative to screening in earlier cohorts.

Patients in the control groups had higher rates of pyelonephritis than those in the treatment groups in all but one of the studies.25 Pooled analysis demonstrated a 76% reduction in pyelonephritis among the intervention groups (pooled relative risk [RR], 0.24 [95% CI, 0.14-0.40]; 12 studies; n = 2068).2 A sensitivity analysis that removed studies deemed to have high risk of bias demonstrated a similar risk reduction (pooled RR, 0.19 [95% CI, 0.11-0.34]; 7 studies; n = 1184).2

Seven treatment studies reported on the incidence of low birth weight. The pooled analysis found statistically significant reductions in the incidence of infants with low birth weight (pooled RR, 0.64 [95% CI, 0.46-0.90]; 7 studies; n = 1522).2 Preterm birth and perinatal mortality were reported in 3 and 6 studies, respectively. For both outcomes, results were mixed and pooled estimates did not demonstrate statistical significance.

Nonpregnant Adults

No studies were identified that directly evaluated the benefits of screening for asymptomatic bacteriuria in the general adult population. Five trials (n = 777)32-36 addressed the benefits of treatment of screen-detected asymptomatic bacteriuria in general adult populations. All 5 studies included participants who had 2 consecutive positive screening urine cultures using a midstream, clean-catch urine sample and using a cutoff of greater than 100 000 CFU/mL. Across all studies, 84% to 100% of participants were women. One study included women aged 20 to 65 years without diabetes, 1 study included only women with diabetes (mean age, 55 years), and 3 studies included only older patients living in independent living facilities. In general, characteristics of participants were sparsely reported across studies, with none reporting on race/ethnicity. Treatment varied across trials, ranging from a single dose to 3 months of antibiotics. No study found a difference in the rates of symptomatic infections or mortality between treated and untreated groups.2

Evidence on Harms of Screening and Treatment
Pregnant Persons

One cohort study (n = 186) that compared screened and unscreened pregnant women reported on potential harms (congenital abnormalities) associated with the screening program, with no meaningful differences reported.18

Seven studies reported on harms associated with treatment of screen-detected asymptomatic bacteriuria.20,22-24,28,29,31 Five studies (n = 961) reported on congenital malformations. All but 1 study reported fewer cases in the intervention group, although the number of cases was small and pooled estimates were not statistically significant.2 Other infant or fetal harms, such as jaundice (2 studies), respiratory distress (1 study), and neonatal sepsis (1 study) were sparsely reported and event rates were low, which limited comparisons.2 Adverse reactions to medications were reported in 2 studies; vaginitis and diarrhea were associated with ampicillin, and nausea and rashes were reported with use of nalidixic acid and nitrofurantoin.2 Complications of pregnancy and delivery (such as third-trimester hemorrhage, premature rupture of the membranes, nonspontaneous onset of labor, or cesarean delivery before onset of labor) were inconsistently and sparsely reported, limiting any conclusions.2

Nonpregnant Adults

Two studies of treatment in nonpregnant women34,36 and 2 studies in older adults32,35 reported on rates of adverse events associated with treatment of asymptomatic bacteriuria. Overall, harms were not reported consistently, which limited the conclusions that could be drawn from the current evidence base.

No studies were identified that addressed the harms of screening for asymptomatic bacteriuria in nonpregnant adults.

How Does Evidence Fit With Biological Understanding?

The relationship between asymptomatic bacteriuria and adverse pregnancy outcomes is related to a combination of factors. Women are at increased risk of urinary tract infections, including asymptomatic bacteriuria, because of the anatomical placement of the urethra.2 Conditions such as increased blood glucose levels and urinary stasis (in which the bladder is unable to completely empty) can increase risk for symptomatic urinary tract infections and pyelonephritis. Pregnancy further increases the risk because of changes in urine pH, bladder compression, and urethral dilation.37 Pyelonephritis in pregnancy has been associated with worse pregnancy outcomes.9,37,38 Screening for and treatment of asymptomatic bacteriuria in pregnant persons could prevent cases of pyelonephritis and associated negative pregnancy outcomes.

Antibiotics are the mainstay treatment for urinary tract infections, but there are consequences to their use. The use of antibiotics is known to lead to antimicrobial resistance. In addition, there is emerging evidence that bacterial colonization of the gastrointestinal and genitourinary tracts plays a protective role. Antibiotic use can disrupt these effects.

Response to Public Comment

A draft version of this recommendation statement was posted for public comment on the USPSTF website from April 23 through May 20, 2019. Commenters requested more information about how the USPSTF assessed older evidence. The USPSTF recognizes that older studies have certain limitations. However, in reviewing all available evidence on the benefits and harms of treating screen-detected asymptomatic bacteriuria in pregnant women, the USPSTF found the evidence to be adequate. Several comments sought clarification on the USPSTF’s rationale for changing the grade of the recommendation from an “A” to a “B” for pregnant persons. A change in grade may occur when evidence has increased or decreased and results in a change in the certainty or magnitude of net benefit.39 Newer evidence, such as the lower prevalence of pyelonephritis and a better understanding of the harms associated with antibiotic use, changed the USPSTF’s assessment of both the certainty (from high to moderate certainty) and net benefit of screening (from substantial to moderate net benefit), leading to the grade change.

Research Needs and Gaps

The USPSTF identified several gaps in the evidence where more research is needed:

  • There were few studies that examined asymptomatic bacteriuria and risk of serious outcomes (ie, pyelonephritis or urosepsis) in modern pregnant populations. Epidemiologic evidence suggests that the prevalence of asymptomatic bacteriuria has been low in recent decades, and many antibiotics used in older studies are no longer recommended for use in pregnancy. More observational studies examining this would help improve the applicability of the evidence base.

  • Clinical trials, observational studies, and natural experiments in settings where asymptomatic bacteriuria screening and treatment are not the standard of care or where guidelines are changing would be useful in assessing benefits and harms.

  • Newer understandings of the human microbiome suggest that bacterial colonization may play a protective role in both mothers and babies. For pregnant and nonpregnant populations, research is needed to better understand the microbiology of a healthy urinary tract and the natural history of asymptomatic bacteriuria.

  • The role of current patterns of antibiotic use in the epidemiology of asymptomatic bacteriuria is unclear. Antibiotic use increases the risk of antimicrobial resistance and can change the microbiome. More research is needed to better understand potential harms of treatment and the effects of antibiotic use on newborn, child, and longer-term health.

Recommendations of Others

The Infectious Diseases Society of America recommends screening for asymptomatic bacteriuria in pregnant women and treatment for those who screen positive.40 The American College of Obstetricians and Gynecologists endorses the Infectious Diseases Society of America’s recommendations for screening for asymptomatic bacteriuria in pregnant women and treatment for those who screen positive. The Canadian Task Force on Preventive Health Care recommends screening in pregnant women with urine culture once during the first trimester, although this was issued as a “weak” recommendation and the quality of evidence was considered low.41 The American Academy of Pediatrics (AAP) has no specific recommendation to screen for asymptomatic bacteriuria in pregnant persons. However, the AAP recommends that clinicians treat pregnant persons and perform a test of cure if asymptomatic bacteriuria is found to be present on a urine culture. In 2008, the American Academy of Family Physicians recommended screening in pregnant women at 12 to 16 weeks of gestation or at the first prenatal visit, whichever comes first.42

The AAP, the American Academy of Family Physicians, and the United Kingdom’s National Institute for Health and Care Excellence all recommend against screening for and treatment of asymptomatic bacteriuria in nonpregnant adults.42-44 The American College of Obstetricians and Gynecologists recommends against screening for and treatment of asymptomatic bacteriuria in nonpregnant, premenopausal women.45

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Article Information

Corresponding Author: Douglas K. Owens, MD, MS, Stanford University, 616 Serra St, Encina Hall, Room C336, Stanford, CA 94305-6019 (chair@uspstf.net).

Correction: This article was corrected on October 11, 2019, for incorrect information in an author affiliation.

Accepted for Publication: August 8, 2019.

The US Preventive Services Task Force (USPSTF) members: Douglas K. Owens, MD, MS; Karina W. Davidson, PhD, MASc; Alex H. Krist, MD, MPH; Michael J. Barry, MD; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; Melissa A. Simon, MD, MPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD.

Affiliations of The US Preventive Services Task Force (USPSTF) members: Veterans Affairs Palo Alto Health Care System, Palo Alto, California (Owens); Stanford University, Stanford, California (Owens); Feinstein Institute for Medical Research at Northwell Health, Manhasset, New York (Davidson); Fairfax Family Practice Residency, Fairfax, Virginia (Krist); Virginia Commonwealth University, Richmond (Krist); Harvard Medical School, Boston, Massachusetts (Barry); University of California, San Francisco (Cabana); Oregon Health & Science University, Portland (Caughey); Mayo Clinic, Rochester, Minnesota (Doubeni); Virginia Tech Carilion School of Medicine, Roanoke (Epling Jr); Temple University, Philadelphia, Pennsylvania (Kubik); University of Alabama at Birmingham (Landefeld); University of California, Los Angeles (Mangione); University of Massachusetts Medical School, Worcester (Pbert); Boston University, Boston, Massachusetts (Silverstein); Northwestern University, Evanston, Illinois (Simon); University of Hawaii, Honolulu (Tseng); Pacific Health Research and Education Institute, Honolulu, Hawaii (Tseng); Tufts University School of Medicine, Boston, Massachusetts (Wong).

Author Contributions: Dr Owens had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The USPSTF members contributed equally to the recommendation statement.

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Authors followed the policy regarding conflicts of interest described at https://www.uspreventiveservicestaskforce.org/Page/Name/conflict-of-interest-disclosures. Dr Barry reported receiving grants and personal fees from Healthwise, a nonprofit, outside the submitted work. All members of the USPSTF receive travel reimbursement and an honorarium for participating in USPSTF meetings. No other disclosures were reported.

Funding/Support: The USPSTF is an independent, voluntary body. The US Congress mandates that the Agency for Healthcare Research and Quality (AHRQ) support the operations of the USPSTF.

Role of the Funder/Sponsor: AHRQ staff assisted in the following: development and review of the research plan, commission of the systematic evidence review from an Evidence-based Practice Center, coordination of expert review and public comment of the draft evidence report and draft recommendation statement, and the writing and preparation of the final recommendation statement and its submission for publication. AHRQ staff had no role in the approval of the final recommendation statement or the decision to submit for publication.

Disclaimer: Recommendations made by the USPSTF are independent of the US government. They should not be construed as an official position of AHRQ or the US Department of Health and Human Services.

Additional Contributions: We thank Justin Mills, MD, MPH (AHRQ), who contributed to the writing of the manuscript, and Lisa Nicolella, MA (AHRQ), who assisted with coordination and editing.

Additional Information: The US Preventive Services Task Force (USPSTF) makes recommendations about the effectiveness of specific preventive care services for patients without obvious related signs or symptoms. It bases its recommendations on the evidence of both the benefits and harms of the service and an assessment of the balance. The USPSTF does not consider the costs of providing a service in this assessment. The USPSTF recognizes that clinical decisions involve more considerations than evidence alone. Clinicians should understand the evidence but individualize decision-making to the specific patient or situation. Similarly, the USPSTF notes that policy and coverage decisions involve considerations in addition to the evidence of clinical benefits and harms.

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