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Biotech Innovations
January 14, 2020

Testing Hypothermic Preservation for Trauma Patients

JAMA. 2020;323(2):111. doi:10.1001/jama.2019.21594

Only 1 in 20 patients survive cardiac arrest from trauma-related blood loss. “Surgeons don’t have time to stop the bleeding before irreversible damage occurs to the brain and other vital organs,” trauma surgeon Samuel A. Tisherman, MD, of the University of Maryland School of Medicine in Baltimore, said in an email.

Tisherman is leading an ongoing phase 2 trial in which approximately 10 patients with penetrating trauma who suffer cardiac arrest and don’t respond to standard resuscitation will undergo emergency preservation and resuscitation (EPR). In this technique, a large amount of ice-cold saline is pumped into the aorta to quickly cool the brain and heart, followed by the rest of the body.

The brain can tolerate 5 to 10 minutes without blood flow at normal temperature, but cooling to around 50 °F can increase the time to at least 45 to 60 minutes, according to Tisherman. “As the surgeons rapidly repair the injuries, we place the patient on a heart-lung machine to restore blood flow and slowly start rewarming,” he said.

New Scientist recently reported on the “suspended animation” study, which began in 2015 and will continue through late this year. Tisherman said he could not discuss patient outcomes until then. But if successful, EPR could be expanded to other trauma patients, such as those with blunt trauma.