[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.175.121.230. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
1.
Chou  R, Dana  T, Fu  R,  et al.  Screening for Hepatitis C Virus Infection in Adolescents and Adults: A Systematic Review Update for the U.S. Preventive Services Task Force: Evidence Synthesis No. 188. Agency for Healthcare Research and Quality; 2020. AHRQ publication 19-05256-EF-1.
2.
Ly  KN, Hughes  EM, Jiles  RB, Holmberg  SD.  Rising mortality associated with hepatitis C virus in the United States, 2003-2013.  Clin Infect Dis. 2016;62(10):1287-1288. doi:10.1093/cid/ciw111PubMedGoogle ScholarCrossref
3.
Centers for Disease Control and Prevention. Hepatitis C questions and answers for health professionals. Published 2017. Accessed January 23, 2020. https://www.cdc.gov/hepatitis/hcv/hcvfaq.htm
4.
Edlin  BR, Eckhardt  BJ, Shu  MA, Holmberg  SD, Swan  T.  Toward a more accurate estimate of the prevalence of hepatitis C in the United States.  Hepatology. 2015;62(5):1353-1363. doi:10.1002/hep.27978PubMedGoogle ScholarCrossref
5.
Rosenberg  ES, Hall  EW, Sullivan  PS,  et al.  Estimation of state-level prevalence of hepatitis C virus infection, US States and District of Columbia, 2010.  Clin Infect Dis. 2017;64(11):1573-1581. doi:10.1093/cid/cix202PubMedGoogle ScholarCrossref
6.
Hofmeister  MG, Rosenthal  EM, Barker  LK,  et al.  Estimating prevalence of hepatitis C virus infection in the United States, 2013-2016.  Hepatology. 2019;69(3):1020-1031. doi:10.1002/hep.30297PubMedGoogle ScholarCrossref
7.
Centers for Disease Control and Prevention. Surveillance for viral hepatitis—United States, 2017. Published November 14, 2019. Accessed January 23, 2020. https://www.cdc.gov/hepatitis/statistics/2017surveillance/index.htm
8.
US Preventive Services Task Force. Procedure Manual. Published June 2018. Accessed January 23, 2020. https://www.uspreventiveservicestaskforce.org/Page/Name/procedure-manual
9.
Chou  R, Clark  E, Helfand  M.  Screening for Hepatitis C Virus Infection: Systematic Evidence Review No. 24. Agency for Healthcare Research and Quality; 2004.
10.
Koneru  A, Nelson  N, Hariri  S,  et al.  Increased hepatitis C virus (HCV) detection in women of childbearing age and potential risk for vertical transmission—United States and Kentucky, 2011-2014.  MMWR Morb Mortal Wkly Rep. 2016;65(28):705-710. doi:10.15585/mmwr.mm6528a2PubMedGoogle ScholarCrossref
11.
Ly  KN, Jiles  RB, Teshale  EH, Foster  MA, Pesano  RL, Holmberg  SD.  Hepatitis C virus infection among reproductive-aged women and children in the United States, 2006 to 2014.  Ann Intern Med. 2017;166(11):775-782. doi:10.7326/M16-2350PubMedGoogle ScholarCrossref
12.
Chou  R, Wasson  N.  Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review.  Ann Intern Med. 2013;158(11):807-820. doi:10.7326/0003-4819-158-11-201306040-00005PubMedGoogle ScholarCrossref
13.
Turner  BJ, Rochat  A, Lill  S,  et al.  Hepatitis C virus screening and care: complexity of implementation in primary care practices serving disadvantaged populations.  Ann Intern Med. Published online December 3, 2019. doi:10.7326/M18-3573PubMedGoogle Scholar
14.
Tran  TT, Ahn  J, Reau  NS.  ACG clinical guideline: liver disease and pregnancy.  Am J Gastroenterol. 2016;111(2):176-194. doi:10.1038/ajg.2015.430PubMedGoogle ScholarCrossref
15.
American Association for the Study of Liver Diseases, Infectious Diseases Society of America. HCV testing and linkage to care. Accessed January 23, 2020. https://www.hcvguidelines.org/full-report/hcv-testing-and-linkage-care
16.
Centers for Disease Control and Prevention. Testing recommendations for hepatitis C virus infection. Accessed January 23, 2020. https://www.cdc.gov/hepatitis/hcv/guidelinesc.htm
17.
Owens  DK, Davidson  KW, Krist  AH,  et al; US Preventive Services Task Force.  Screening for hepatitis B virus infection in pregnant women: US Preventive Services Task Force reaffirmation recommendation statement.  JAMA. 2019;322(4):349-354. doi:10.1001/jama.2019.9365PubMedGoogle ScholarCrossref
18.
LeFevre  ML; US Preventive Services Task Force.  Screening for hepatitis B virus infection in nonpregnant adolescents and adults: U.S. Preventive Services Task Force recommendation statement.  Ann Intern Med. 2014;161(1):58-66. doi:10.7326/M14-1018PubMedGoogle ScholarCrossref
19.
Owens  DK, Davidson  KW, Krist  AH,  et al; US Preventive Services Task Force.  Screening for HIV infection: US Preventive Services Task Force recommendation statement.  JAMA. 2019;321(23):2326-2336. doi:10.1001/jama.2019.6587PubMedGoogle ScholarCrossref
20.
Moyer  VA; US Preventive Services Task Force.  Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force recommendation statement.  Ann Intern Med. 2013;159(5):349-357. doi:10.7326/0003-4819-159-5-201309030-00672PubMedGoogle ScholarCrossref
21.
Chou  R, Dana  T, Fu  R,  et al.  Screening for hepatitis C virus infection in adolescents and adults: updated evidence report and systematic review for the US Preventive Services Task Force.  JAMA. Published online March 2, 2020. doi:10.1001/jama.2019.20788Google Scholar
22.
Mast  EE, Hwang  LY, Seto  DS,  et al.  Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy.  J Infect Dis. 2005;192(11):1880-1889. doi:10.1086/497701PubMedGoogle ScholarCrossref
23.
Barocas  JA, Tasillo  A, Eftekhari Yazdi  G,  et al.  Population-level outcomes and cost-effectiveness of expanding the recommendation for age-based hepatitis C testing in the United States.  Clin Infect Dis. 2018;67(4):549-556. doi:10.1093/cid/ciy098PubMedGoogle ScholarCrossref
24.
Chou  R, Cottrell  E, Wasson  N,  et al.  Screening for Hepatitis C Virus Infection in Adults: Comparative Effectiveness Review No. 69. Agency for Healthcare Research and Quality; 2012. AHRQ publication 12(13)-EHC090-EF.
25.
Centers for Disease Control and Prevention. CDC recommendations for hepatitis C screening among adults. Accessed January 23, 2020. https://www.cdc.gov/hepatitis/policy/pdfs/CDC-2019-0094-0002.pdf
26.
American College of Obstetricians and Gynecologists.  ACOG Practice Bulletin No. 86: viral hepatitis in pregnancy.  Obstet Gynecol. 2007;110(4):941-956. doi:10.1097/01.AOG.0000263930.28382.2aPubMedGoogle ScholarCrossref
27.
Ghany  MG, Morgan  TR; AASLD-IDSA Hepatitis C Guidance Panel.  Hepatitis C guidance 2019 update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America recommendations for testing, managing, and treating hepatitis C virus infection.  Hepatology. 2020;71(2):686-721. doi:10.1002/hep.31060PubMedGoogle ScholarCrossref
US Preventive Services Task Force
Recommendation Statement
March 2, 2020

Screening for Hepatitis C Virus Infection in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

US Preventive Services Task Force
JAMA. 2020;323(10):970-975. doi:10.1001/jama.2020.1123
Abstract

Importance  Hepatitis C virus (HCV) is the most common chronic blood-borne pathogen in the US and a leading cause of complications from chronic liver disease. HCV is associated with more deaths than the top 60 other reportable infectious diseases combined, including HIV. Cases of acute HCV infection have increased approximately 3.8-fold over the last decade because of increasing injection drug use and improved surveillance.

Objective  To update its 2013 recommendation, the USPSTF commissioned a review of the evidence on screening for HCV infection in adolescents and adults.

Population  This recommendation applies to all asymptomatic adults aged 18 to 79 years without known liver disease.

Evidence Assessment  The USPSTF concludes with moderate certainty that screening for HCV infection in adults aged 18 to 79 years has substantial net benefit.

Recommendation  The USPSTF recommends screening for HCV infection in adults aged 18 to 79 years. (B recommendation)

×