[Skip to Content]
[Skip to Content Landing]
Views 36,215
Citations 0
JAMA Insights
June 5, 2020

Caring for Women Who Are Planning a Pregnancy, Pregnant, or Postpartum During the COVID-19 Pandemic

Author Affiliations
  • 1Department of Pediatrics, University of Florida College of Medicine, Gainesville
  • 2Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville
  • 3Emory University School of Medicine, Department of Gynecology and Obstetrics, Atlanta, Georgia
JAMA. 2020;324(2):190-191. doi:10.1001/jama.2020.8883

Since its recognition in China in December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world and become a pandemic. Although considerable data on COVID-19 are available, much remains to be learned about its effects on pregnant women and newborns.

No data are currently available to assess whether pregnant women are more susceptible to COVID-19. Pregnant women are at risk for severe disease associated with other respiratory illnesses (eg, 2009 H1N1 influenza),1 but thus far, pregnant women with COVID-19 do not appear to be at increased risk for severe disease compared with the general population. Data from China showed that among 147 pregnant women, 8% had severe disease and 1% had critical illness, which are lower rates than observed in the nonpregnant population (14% with severe disease and 6% with critical illness).2 Case series from China consisting primarily of women with third-trimester infection have shown that clinical findings in pregnant women are similar to those seen in the general population.1 Conversely, a small Swedish study reported that pregnant and postpartum women with COVID-19 were 5 times more likely to be admitted to an intensive care unit compared with nonpregnant women of similar age.3

Data on pregnant women with COVID-19 in the US are beginning to accumulate. For example, a recent report included 43 pregnant women with COVID-19 who presented for care at 2 hospitals in New York City.4 Although this case series did not include a nonpregnant control group, the proportion of pregnant women with severe disease was similar to that described in nonpregnant adults with COVID-19.4 More information is needed about the effect of pregnancy and comorbidities to understand how they affect clinical outcomes of COVID-19. The US experience might differ from other countries because of the high frequency of comorbidities among pregnant women in the US.

The effects of COVID-19 during pregnancy on the neonate are not well understood. Nearly all infections reported from China were during the third or late-second trimester, so whether first-trimester SARS-CoV-2 infection might cause birth defects or pregnancy loss is unknown. Some newborns born to mothers with COVID-19 during pregnancy were born preterm or of low birth weight, but whether these outcomes were COVID-19–related is unclear. SARS-CoV-2 transmission from a mother to her newborn could occur prenatally, perinatally, or postnatally. In most newborns tested after birth, results have been negative for SARS-CoV-2.1 However, symptomatic newborns born to mothers with COVID-19 have been reported to have SARS-CoV-2 infection at a few days of life5; whether this was due to prenatal, perinatal, or postnatal transmission is unknown. Recently, a probable case of congenital infection was reported in a newborn born to a woman with familial neutropenia who was diagnosed with COVID-19 before delivery. A neonatal nasopharyngeal swab collected on the day of birth prior to skin-to-skin maternal contact was positive.6 The presence of IgM and IgG antibodies in 3 infants born to mothers with COVID-19 during pregnancy was recently reported.7 IgG antibodies freely cross the placenta; however, IgM antibodies do not typically cross the placenta, suggesting the possibility of prenatal transmission of SARS-CoV-2. However, these studies do not provide definitive evidence for intrauterine transmission because cross-reactivity and false-positive IgM test results can occur.7 Whether transmission can occur through breastfeeding is unknown. SARS-CoV-2 RNA has been detected in breastmilk samples from a single woman with COVID-19, and her infant tested positive for SARS-CoV-2, but whether the infant was infected through breastfeeding is unclear.8 Given the benefits of breast milk, when feasible, breast milk should be fed to infants regardless of maternal COVID-19 status.

Based on experiences with other infections (eg, influenza), adverse effects on the fetus or newborn related to prenatal infection might occur even without intrauterine transmission. For example, severe maternal illness with influenza requiring intensive care unit admission was associated with increased risks for preterm birth, low birth weight, and low Apgar scores.9 Whether an increased risk for adverse outcomes among newborns born to women with COVID-19 will be seen is unknown.

Given the limited data, recommendations for caring for women who are planning a pregnancy, pregnant, or have given birth during the COVID-19 pandemic are based on expert opinion. Women planning a pregnancy in the time of COVID-19 might ask whether they should delay pregnancy until after the pandemic. Based on limited data, there does not seem to be a compelling reason to recommend delaying pregnancy. For women who are pregnant, the primary recommendation is to avoid becoming infected with SARS CoV-2 through hygiene and social distancing measures. Early recognition of COVID-19 in a pregnant patient admitted to a labor and delivery unit is necessary so appropriate infection control practices can be instituted. Given that some women with COVID-19 might be asymptomatic or presymptomatic, health care facilities may consider polymerase chain reaction testing for SARS-CoV-2 at the time of admission.

Guidelines for the care of pregnant women known or suspected to have COVID-19 admitted for delivery have been developed by the Centers for Disease Control and Prevention (CDC) and several professional organizations (Box). On presentation, a mask should be placed on the woman and she should be isolated in a single-patient room with the door closed, with an airborne isolation room used for aerosol-generating procedures. Clinical care of a pregnant woman with COVID-19 should be based on illness severity; diagnostic measures and treatments should not be withheld based on pregnancy status. Given the risks of maternal respiratory depression, consideration should be given to limiting the use of magnesium sulfate for seizure prophylaxis and fetal neuroprotection. Given concerns about potential harm from corticosteroid use in patients with COVID-19, antenatal corticosteroid use for fetal maturation should be carefully considered and should depend on the gestational age. Early epidural analgesia should be considered to mitigate the risks associated with general anesthesia in the setting of an urgent cesarean delivery. Decisions regarding timing and mode of delivery should be based on standard fetal and maternal indications.

Box Section Ref ID
Box.

Recommendations for Care of Pregnant Women Confirmed or Suspected to Have Coronavirus Disease 2019 (COVID-19)

Recommendations
  • Place a mask on the patient on presentation and isolate in a single-person room with the door closed. Airborne isolation rooms should be used for aerosolizing procedures (ACOG, CDC, SMFM, SOAP).

  • Consider separating patients with COVID-19 in one area of the obstetric unit and using a designated team of trained clinicians in these areas (SMFM, SOAP).

  • Weigh benefits and risks of magnesium sulfate for fetal neuroprotection or for preeclampsia/intrapartum seizure prophylaxis given potential maternal respiratory depression (SMFM, SOAP).

  • Consider adjusting antenatal corticosteroid use for fetal maturation, given the risk of worsening patient outcomes with corticosteroid use in patients with COVID-19 (eg, offer antenatal steroids for patients <34 weeks’ gestation, weigh risks and benefits and individualize decisions for ≥34 weeks’ gestation) (ACOG, SMFM, SOAP).

  • Consider early epidural analgesia to mitigate the risks associated with general anesthesia in the setting of an urgent cesarean delivery (SMFM, SOAP).

  • Do not alter delivery timing or mode (eg, cesarean delivery, operative vaginal delivery) due to patients’ COVID-19 infection status. However, for women with COVID-19 in the third trimester, it may be reasonable to attempt to postpone delivery to decrease risk of neonatal transmission (ACOG).

  • Consider temporary separation of mothers with confirmed COVID-19 from their newborns (ACOG, AAP, CDC).

  • Determination of whether to temporarily separate a mother with known or suspected COVID-19 should be made on a case-by-case basis, using shared decision-making (ACOG, CDC).

  • If temporary separation is chosen, mothers who intend to breastfeed should practice hand and breast hygiene and express their milk. Expressed milk can be fed to the newborn by a healthy caregiver (ACOG, AAP, CDC, SMFM, SOAP).

  • If separation is not chosen, use other measures to reduce risk of infection, such as physical barriers and face mask use by the mother (AAP, CDC).

  • Mothers who choose to feed at the breast should wear a face mask and practice hand and breast hygiene before each feeding (AAP, ACOG, CDC, SMFM, SOAP).

  • Newborns born to mothers with confirmed COVID-19 at the time of delivery should be considered to have suspected COVID-19 and be isolated from healthy newborns (AAP, ACOG, CDC).

  • Newborns born to mothers with confirmed or suspected COVID-19 at the time of delivery should be tested 24 hours after birth for SARS-CoV-2 and, if negative, again at approximately 48 hours if testing capacity is available (AAP, CDC).

Professional Organization Resources

Issues related to hospital placement of the newborn born to a mother with known or suspected COVID-19 are challenging. Measures to reduce the risk of transmission from an infected mother to her newborn include placing them in separate rooms or using other controls (eg, physical barriers, the mother wearing a face mask during contact with the newborn); shared decision-making between the mother and the care team regarding this issue is recommended. For those who select temporary separation, expression of breast milk with careful hand and breast hygiene should be encouraged, with feeding of the breast milk done by a healthy caregiver. A mother who chooses to room with her newborn should use a face mask and careful hand and breast hygiene before breastfeeding. Newborns born to mothers with COVID-19 at delivery should be considered to have suspected COVID-19 and isolated from healthy newborns.

Information on COVID-19 is changing rapidly. As additional data become available recommendations might change, so clinicians should follow the CDC website and those of professional organizations for updates.

Back to top
Article Information

Corresponding Author: Denise J. Jamieson, MD, MPH, Department of Gynecology and Obstetrics, Emory University School of Medicine, 101 Woodruff Cir, Woodruff Memorial Research Building, Ste 4208, Atlanta, GA 30322 (djamieson@emory.edu).

Published Online: June 5, 2020. doi:10.1001/jama.2020.8883

Conflict of Interest Disclosures: None reported.

References
1.
Rasmussen  SA, Smulian  JC, Lednicky  JA, Wen  TS, Jamieson  DJ.  Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know.   Am J Obstet Gynecol. 2020;222(5):415-426.PubMedGoogle ScholarCrossref
2.
Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). World Health Organization; 2020. Accessed March 8, 2020. https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf
3.
Collin  J, Byström  E, Carnahan  A, Ahrne  M.  Pregnant and postpartum women with SARS-CoV-2 infection in intensive care in Sweden.   Acta Obstet Gynecol Scand. Published online May 9, 2020. doi:10.1111/aogs.13901PubMedGoogle Scholar
4.
Breslin  N, Baptiste  C, Muller  R,  et al.  Coronavirus disease 2019 in pregnancy: early lessons.   Am J Obstet Gynecol. Published online May 20, 2020. doi:10.1016/j.ajogmf.2020.100111Google Scholar
5.
Zeng  L, Xia  S, Yuan  W,  et al.  Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China.   JAMA Pediatr. Published online March 26, 2020. doi:10.1001/jamapediatrics.2020.0878PubMedGoogle Scholar
6.
Kirtsman  M, Diambomba  Y, Poutanen  SM,  et al.  Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection.   CMAJ. Published online May 14, 2020. doi:10.1503/cmaj.200821PubMedGoogle Scholar
7.
Kimberlin  DW, Stagno  S.  Can SARS-CoV-2 infection be acquired in utero? more definitive evidence is needed.   JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4868PubMedGoogle Scholar
8.
Groß  R, Conzelmann  C, Müller  JA,  et al.  Detection of SARS-CoV-2 in human breastmilk.   Lancet. Published online May 21, 2020. doi:10.1016/S0140-6736(20)31181-8PubMedGoogle Scholar
9.
Newsome  K, Alverson  CJ, Williams  J,  et al.  Outcomes of infants born to women with influenza A(H1N1)pdm09.   Birth Defects Res. 2019;111(2):88-95.PubMedGoogle ScholarCrossref
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    1 Comment for this article
    EXPAND ALL
    Uncertainties are the Reasons to Postpone Pregnancy if Possible
    Bruno Carvalho, MD | Hospital Sírio-Libanês Brasília, DF, Brazil
    In addition to women who are planning a pregnancy, health professionals and society as a whole have doubts about the risks of pregnancy during the epidemic of the disease caused by the new coronavirus. Consequently, such doubts raise the question about the possible benefit of postponing reproductive plans to post-COVID-19. The authors seem to me to be categorical in stating that, due to limited data available, there does not seem to be a convincing reason for recommending postponing pregnancy. However, in their argument, the authors list today's uncertainties: (1) there is no sufficiently robust evidence to state that the evolution of COVID-19 is similar in pregnant and non-pregnant women; (2) it cannot be said that the placental barrier is capable of preventing the vertical transmission of SARS-CoV-2; (3) it is not known whether infection by SARS-CoV-2 in the first trimester can cause birth defects or pregnancy loss; (4) it is not known whether transmission of SARS-CoV-2 can occur through breastfeeding; and, finally, (5) it is not known whether children born to mothers infected by the SARS-CoV-2 will have the same clinical evolution as children born to healthy mothers. Thus, I venture to oppose the authors and say that the 5 uncertainties are 5 reasons for counseling against pregnancy at this time, if it is possible. Based on the various existing studies, it is important to say that the deleterious effect of postponing pregnancy by a few months does not seem to be significant, even for women of advanced reproductive age or with diminished ovarian reserve. In this few months' time, we will certainly still not be free from the pandemic, but we will have more data available and have mitigated uncertainties, which will allow better counseling for reproductive plans to be resumed in a scenario of living with a less unknown virus. Finally, it should be said that guidelines should be based on the observation of the disease curve in each location, independently, especially in countries where the number of cases of COVID-19 is still on the rise.
    CONFLICT OF INTEREST: None Reported
    READ MORE
    ×