Persistent Symptoms in Patients After Acute COVID-19 | Critical Care Medicine | JAMA | JAMA Network
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    2 Comments for this article
    Post-Covid-19 Sequelae and Follow up
    Khichar Shubhakaran, MD(Med), D.M.(Neurology) | Senior Professor and head of Department of Neurology, MDM Hospital, Dr. S.N. Medical College, Jodhpur, India-342003
    A very important article about persistent symptoms after recovery from Covid-19. Of course all these symptoms may have some component of psychology but the persistent symptoms are definitely organic and may have a long term impact on overall health care all over the globe.

    All these symptoms require close follow up, as pulmonary fibrosis in Covid-19 survivors have been reported from Mumbai in India (1), and from Wuhan in China also.

    While awaiting a vaccine for prevention, the understanding of the various sequelae of Covid-19 will help in studying the effects of interventions, like steroids and other immune
    modulators for pulmonary fibrosis (2), on long-term symptoms.


    2. Spagnolo P, Balestro E, Aliberti S et al. Pulmonary fibrosis secondary to COVID-19:a call to arms ?Lancet Respir Med. 2020 Aug; 8(8): 750-752.
    Stress, Anxiety and Mental Health During COVID-19
    Michael McAleer, PhD(Econometrics),Queen's | Asia University, Taiwan
    Persistent symptoms after patients have been diagnosed with COVID-19 are of deep concern, especially if the end-point is unknown.

    Associated with the disease itself, as well as the parallel issues of a socially distanced society and closed economy, are the increased stress, anxiety, and severe mental health issues experienced across all cohorts, but especially for the young and those who suffer socioeconomic inequity and disadvantage.

    Mental health issues are almost certain to worsen as the unknown endpoint of the pandemic stretches well into the future.
    Research Letter
    July 9, 2020

    Persistent Symptoms in Patients After Acute COVID-19

    Angelo Carfì, MD1; Roberto Bernabei, MD1; Francesco Landi, MD, PhD1; et al for the Gemelli Against COVID-19 Post-Acute Care Study Group
    Author Affiliations
    • 1Geriatrics Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
    JAMA. 2020;324(6):603-605. doi:10.1001/jama.2020.12603

    In Italy, a large proportion of patients with coronavirus disease 2019 (COVID-19) presented with symptoms (71.4% of 31 845 confirmed cases as of June 3, 2020).1 Common symptoms include cough, fever, dyspnea, musculoskeletal symptoms (myalgia, joint pain, fatigue), gastrointestinal symptoms, and anosmia/dysgeusia.2-4 However, information is lacking on symptoms that persist after recovery. We assessed persistent symptoms in patients who were discharged from the hospital after recovery from COVID-19.

    In the waning phase of the pandemic, beginning on April 21, 2020, the Fondazione Policlinico Universitario Agostino Gemelli IRCCS in Rome, Italy, established a postacute outpatient service for individuals discharged from the hospital after recovery from COVID-19. All patients who met World Health Organization criteria for discontinuation of quarantine (no fever for 3 consecutive days, improvement in other symptoms, and 2 negative test results for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] 24 hours apart) were followed up. At enrollment in the study, real-time reverse transcriptase–polymerase chain reaction for SARS-CoV-2 was performed and patients with a negative test result were included.