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In our program of studies of antisyphilitic remedies, attempts have been made to test the possibilities for penetration of the brain by certain products. If an antisyphilitic agent could be depended on to do this, the prevention and treatment of neurosyphilis would begin at the time of treatment of acute syphilis. This mode of attack on neurosyphilis is desirable, since it is now accepted that Spirochaeta pallida invades the central nervous system early in the course of the disease. The commonly used antisyphilitic drugs cannot be depended on to penetrate the central nervous system without some previous treatment of the patient to increase the efficiency of penetration. Obviously, if a drug could penetrate unaided, the treatment would have decided advantages. The object of this report is to present a preliminary survey of results with a bismuth product which we have found to penetrate the brain.
The bismuth compounds in current
HANZLIK PJ, MEHRTENS HG, GURCHOT C, JOHNSON CC, Spaulding J, Marshall DC. IODOBISMITOL: A SOLUBLE BISMUTH PRODUCT FOR USE IN THE TREATMENT OF SYPHILIS: PRELIMINARY REPORT. JAMA. 1932;98(7):537–542. doi:10.1001/jama.1932.02730330019005
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