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Lipodystrophy is defined by Coates1 as a "disease especially liable to affect children 5 to 8 years of age, in which characteristically there is a loss of subcutaneous fat of the face, neck, thorax, arms and abdomen, without assignable cause or gross symptoms of ill health. In association with this, there is in addition, in females, an increase of subcutaneous fat below the iliac crests."
Like many other diseases, it remained obscure until attention had been sufficiently attracted to it by case reports in the medical periodicals. Thus in 1917, J. Parkes Weber2 summarized twenty-seven cases including his own reported to that date, while in 1924. Reuben, Zamkin and Fox3 found sixty cases recorded and Coates in 1925 summarizes sixty-three cases. In 1927, eight case reports were found and there have been at least five cases reported in children under 14 years since 1927. Barraquer reported the
PARMELEE AH. LIPODYSTROPHY: A REPORT OF SIX CASES IN CHILDREN. JAMA. 1932;98(7):548–552. doi:10.1001/jama.1932.02730330030008
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