All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020 | Infectious Diseases | JAMA | JAMA Network
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    2 Comments for this article
    Interesting Approach to the COVID issue
    Arsen Melkumian, PhD in Economics | Bridgewater State University
    These data look interesting, however I would like to see more results reported. For instance, how well does the seasonal ARIMA fit the data? What do the monthly data for 2015-2019 look like?
    Pandemic COVID-19 and other medical challenges.
    Anatoly Zhirkov, Professor | Saint Petersburg State University
    I read the article with great interest. The authors provide statistics on mortality during the Covid-19 pandemic in the United States. The data are widely discussed from the standpoint of possible causes of death. The authors focus on the role of the COVID-19 pandemic. At the same time, attention is drawn to the fact that the number of deaths from opioid overdose prevails and remains high. Thus, the pandemic is a new problem that does not diminish the importance of opioid addiction. This article clearly demonstrates the need to improve the theory and practice of medicine during an epidemic of disease.
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    Research Letter
    December 16, 2020

    All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020

    Author Affiliations
    • 1Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
    • 2Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut
    • 3Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, Connecticut
    • 4Harvard Affiliated Emergency Medicine Residency, Boston, Massachusetts
    • 5Emergency Medicine Department, Yuma Regional Medical Center, Yuma, Arizona
    • 6Division of Infectious Diseases, Massachusetts General Hospital, Boston
    JAMA. Published online December 16, 2020. doi:10.1001/jama.2020.24243

    Coronavirus disease 2019 (COVID-19) has caused a marked increase in all-cause deaths in the US, mostly among older adults.1 Although the burden of COVID-19 among hospitalized younger adults has been described, fewer data focus on mortality in this demographic, owing to lower case-fatality rates.2

    Excess mortality reflects the full burden of the pandemic that may go uncaptured due to uncoded COVID-19 and other pandemic-related deaths. Accordingly, we examined all-cause excess mortality and COVID-19–related mortality during the early pandemic period among adults aged 25 to 44 years. Because unintentional drug overdoses are the usual leading cause of death in this demographic, COVID-19 deaths were compared with unintentional opioid deaths.