All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020 | Infectious Diseases | JAMA | JAMA Network
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    2 Comments for this article
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    December 18, 2020
    Interesting Approach to the COVID issue
    Arsen Melkumian, PhD in Economics | Bridgewater State University
    These data look interesting, however I would like to see more results reported. For instance, how well does the seasonal ARIMA fit the data? What do the monthly data for 2015-2019 look like?
    CONFLICT OF INTEREST: None Reported
    December 23, 2020
    Pandemic COVID-19 and other medical challenges.
    Anatoly Zhirkov, Professor | Saint Petersburg State University
    I read the article with great interest. The authors provide statistics on mortality during the Covid-19 pandemic in the United States. The data are widely discussed from the standpoint of possible causes of death. The authors focus on the role of the COVID-19 pandemic. At the same time, attention is drawn to the fact that the number of deaths from opioid overdose prevails and remains high. Thus, the pandemic is a new problem that does not diminish the importance of opioid addiction. This article clearly demonstrates the need to improve the theory and practice of medicine during an epidemic of disease.
    CONFLICT OF INTEREST: None Reported
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    Research Letter
    December 16, 2020

    All-Cause Excess Mortality and COVID-19–Related Mortality Among US Adults Aged 25-44 Years, March-July 2020

    Jeremy Samuel Faust, MD, MS1; Harlan M. Krumholz, MD, SM2; Chengan Du, PhD3; et al Katherine Dickerson Mayes, MD, PhD4; Zhenqiu Lin, PhD3; Cleavon Gilman, MD5; Rochelle P. Walensky, MD, MPH6
    Author Affiliations Article Information
    • 1Department of Emergency Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
    • 2Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut
    • 3Center for Outcomes Research and Evaluation, Yale School of Medicine, New Haven, Connecticut
    • 4Harvard Affiliated Emergency Medicine Residency, Boston, Massachusetts
    • 5Emergency Medicine Department, Yuma Regional Medical Center, Yuma, Arizona
    • 6Division of Infectious Diseases, Massachusetts General Hospital, Boston
    JAMA. Published online December 16, 2020. doi:10.1001/jama.2020.24243
    COVID-19 Resource Center
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    Coronavirus disease 2019 (COVID-19) has caused a marked increase in all-cause deaths in the US, mostly among older adults.1 Although the burden of COVID-19 among hospitalized younger adults has been described, fewer data focus on mortality in this demographic, owing to lower case-fatality rates.2

    Excess mortality reflects the full burden of the pandemic that may go uncaptured due to uncoded COVID-19 and other pandemic-related deaths. Accordingly, we examined all-cause excess mortality and COVID-19–related mortality during the early pandemic period among adults aged 25 to 44 years. Because unintentional drug overdoses are the usual leading cause of death in this demographic, COVID-19 deaths were compared with unintentional opioid deaths.

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