Pregnant People’s Paradox—Excluded From Vaccine Trials Despite Having a Higher Risk of COVID-19 Complications | Pregnancy | JAMA | JAMA Network
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February 24, 2021

Pregnant People’s Paradox—Excluded From Vaccine Trials Despite Having a Higher Risk of COVID-19 Complications

JAMA. 2021;325(11):1027-1028. doi:10.1001/jama.2021.2264

Kristina Adams Waldorf, MD, recently coauthored a study that found a higher risk of hospitalization and death among people with coronavirus disease 2019 (COVID-19) who were pregnant than among those who weren’t pregnant.

Still, 1 of her patients, a pregnant health care worker, “is kind of unsure” about whether she should get vaccinated, Adams Waldorf, an obstetrician-gynecologist at the University of Washington, said in an interview. The patient worries that a COVID-19 vaccine could harm her fetus.

No wonder she is concerned.

All the COVID-19 vaccine trials, like virtually all clinical trials, have excluded pregnant and lactating individuals from participating; however, developmental and reproductive toxicity studies with the Moderna vaccine in rats haven’t uncovered any worrisome signals.

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    1 Comment for this article
    It's Unethical to Not Recommend COVID-19 Vaccination in Pregnancy
    Amos Grunebaum, MD, Professor | Lenox Hill Hospital, Zucker School of medicine
    This article clearly outlines the present problem. Despite pregnant women being at higher risk of death or disease, no society or other organization wants to say the truth. It's like the emperor's new clothes. Vaccination must be recommended. Anything else is unprofessional, as I and colleague have outlined elsewhere (1).