Study Suggests Lasting Immunity After COVID-19, With a Big Boost From Vaccination | Infectious Diseases | JAMA | JAMA Network
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July 14, 2021

Study Suggests Lasting Immunity After COVID-19, With a Big Boost From Vaccination

JAMA. 2021;326(5):376-377. doi:10.1001/jama.2021.11717
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    5 Comments for this article
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    Inmunidad Duradera Post-Infección Por Covid
    Herminio Renan Hernandez Diaz, Medico Pediatra. | Universidad Peruana Cayetano Heredia,Lima. Perú

    Me parece interesante esta información y que tiene algunas implicancias como: diferir vacunar a quienes ya tuvieron covid, o en todo caso solo ponerles una dosis.

    Me gustaria tener las referencias empleadas en este articulo, no las encontré en la traducción.

    (Google Translate translation:

    I find this information interesting and that it has some implications such as: deferring vaccinating those who have already had covid, or in any case just giving them one dose.

    I would like to have the references used in this article, I did not find them in the translation.)

    CONFLICT OF INTEREST: None Reported
    No clinical benefit shown
    Stephen Holland, MD | Independent practitioner
    Understanding the benefit of immunization after recovery from COVID infection has significant policy implications. This study shows that humoral immunity is measurably increased after immunization. However, I do not see data here to support that patients are now "bulletproof" despite that being an appealing idea.

    Immunity to a viral illness comes both from humoral and cellular immunity. This study showed a 50-fold increase of antibody titer, or 1.5 log units. The study did not assess cellular immunity. Additionally, the study did not show a clinical benefit, since none of the subjects developed a second COVID infection, either clinical
    or subclinical.

    The study does suggest that if one wanted to implement a human immune serum donor system an immunization with an mRNA vaccine would augment antibody levels in serum donors without the need for additional adjuvants.
    CONFLICT OF INTEREST: None Reported
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    Side Effects
    Barry Boston, MD | Retired Oncologist
    What ae the side effects of vaccination in post-COVID 19 patients? How severe are the side effects? Does the benefit from a booster outweigh the side effects of the booster?
    CONFLICT OF INTEREST: None Reported
    Overstatements re Immunity
    David Naftolowitz, MD | Private Practice Psychiatry
    It's quite doubtful that those who have recovered from Covid-19 and are vaccinated are "bulletproof," as quoted, as shown in studies of healthcare workers who have gotten sick after vaccination (and perhaps after prior exposure).

    Likewise, it seems too optimistic for the other researcher quoted to say, "I don't think we will need boosters soon." There are clear exceptions to strong immunity, such as in the very elderly or immunocompromised, who are susceptible to re-infection, and illness, in some cases. The US government is apparently already planning for boosters in these groups.

    Even for the general population, with
    more transmissible, and maybe more virulent, mutations already in evidence, boosters may be necessary.
    CONFLICT OF INTEREST: None Reported
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    Hybrid immunity with Vaccine First?
    Jennifer Reagan |
    I wonder if similar studies will be done for those who have been vaccinated and then develop covid. Would it be beneficial to have a mild breakthrough infection to create hybrid immunity rather than having a booster dose?
    CONFLICT OF INTEREST: None Reported
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