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For many years, primary disease of the coronary arteries (coronary sclerosis) was of interest chiefly to pathologists. In the eighteenth century, Jenner and Parry1 made a clinical diagnosis of coronary disease and had their diagnosis confirmed at necropsy. Then, for a considerable time, coronary sclerosis with occlusion was thought of as occurring mostly in men and only in elderly persons. Coronary thrombosis is more prevalent among males than among females. The ratio given by various writers varies considerably; some consider it to be as high as 10: 1. The disease is not confined to the aged. Commonly in the literature, the terms coronary occlusion, coronary thrombosis, coronary embolism, and myocardial infarction are used interchangeably. The clinical symptoms that accompany acute occlusion of one of the coronary arteries or of one of its main branches are usually characteristic. It is occlusion of the artery, with the resulting infarct, not the
SMITH HL, BARTELS EC. CORONARY THROMBOSIS WITH MYOCARDIAL INFARCTION AND HYPERTROPHY IN YOUNG PERSONS: REPORT OF TWO CASES WITH NECROPSY. JAMA. 1932;98(13):1072–1076. doi:10.1001/jama.1932.02730390026006
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