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News From the JAMA Network
April 5, 2022

Maternal COVID-19 Vaccine Safe for Infants

JAMA. 2022;327(13):1218. doi:10.1001/jama.2022.4370

A study in Israel found that individuals who received an mRNA COVID-19 vaccine during pregnancy delivered infants with no increased risk for morbidity or mortality compared with infants whose birthing parents weren’t vaccinated.

The investigators analyzed 24 288 singleton live births from a health care organization in Israel from March 2021 through September 2021. The study included 16 697 newborns exposed in the first and second trimesters to maternal vaccination with the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech).

Rates of preterm birth and low birth weight were similar between newborns exposed and unexposed to the vaccine. All-cause neonatal hospitalizations, postneonatal hospitalizations, congenital anomalies, and infant mortality also were similar.

The study “contributes to current evidence in establishing the safety of prenatal vaccine exposure to the newborns,” the authors wrote in JAMA Pediatrics.