[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
Purchase Options:
[Skip to Content Landing]
Article
April 23, 1932

HYPERINSULINISM

Author Affiliations

CINCINNATI

JAMA. 1932;98(17):1441-1443. doi:10.1001/jama.1932.02730430017007
Abstract

Definite instances of hyperinsulinism are still sufficiently rare to justify additional reports of such cases. It is indeed remarkable that the disease can be so readily identified, when so few authenticated cases have thus far been reported. The clear cut symptom complex produced by insulin overdosage, and more satisfactory laboratory facilities, have simplified the recognition of the condition. Whether the term "hyperinsulinism" as first used by Seale Harris will continue to be used or whether the designation "spontaneous hypoglycemia" may be a more correct term, especially for the milder types, the future must decide. The multiplicity and variability of the symptoms of hyperinsulinism recall the days when the various forms of thyroid disturbances had not yet been properly correlated and classified. It does not require a far stretch of the imagination to assume that hyperactivity of the islets of Langerhans may logically occur as well as its counterpart, an inadequate

References
1.
Harris, Seale:  Hyperinsulinism and Dysinsulinism ,  J. A. M. A. 83: 729-733 ( (Sept. 6) ) 1924.Crossref
2.
Wilder, R. M.; Allan, F. N.; Power, M. H., and Robertson, H. E.:  Carcinoma of the Islands of the Pancreas ,  J. A. M. A. 89: 348-355 ( (July 30) ) 1927.Crossref
3.
Howland, Goldwin; Campbell, W. R.; Maltby, E. J., and Robinson, W. L.:  Dysinsulinism: Convulsion and Coma Due to Islet Cell Tumor of the Pancreas, with Operation and Cure ,  J. A. M. A. 93: 674-678 ( (Aug. 31) ) 1929.Crossref
4.
McClenahan, W. U., and Norris, G. W.:  Adenoma of the Islands of Langerhans with Associated Hypoglycemia ,  Am. J. M. Sc. 177: 93 ( (Jan.) ) 1929.Crossref
5.
Thalhimer, William; and Murphy, F. D.:  Carcinoma of the Islands of the Pancreas: Hyperinsulinism and Hypoglycemia ,  J. A. M. A. 91: 89 ( (July 14) ) 1928.Crossref
6.
Krause, F.:  Hyperinsulinism mit hypoglykämischen Symptomenkomplex ,  Klin. Wchnschr. 9: 2346 ( (Dec. 13) ) 1930.Crossref
7.
Finney, J. M. T., and Finney, J. M. T., Jr.:  Resecting of the Pancreas ,  Ann. Surg. 88: 584-592 ( (Sept.) ) 1928.Crossref
8.
Nielsen, J. M., and Eggleston, E. L.:  Functional Dysinsulinism with Epileptiform Seizures ,  J. A. M. A. 94: 860-863 ( (March 22) ) 1930.Crossref
9.
Valuable assistance was rendered by Dr. H. I. Katz in collecting the data for this report.
×