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April 23, 1932


Author Affiliations


JAMA. 1932;98(17):1441-1443. doi:10.1001/jama.1932.02730430017007

Definite instances of hyperinsulinism are still sufficiently rare to justify additional reports of such cases. It is indeed remarkable that the disease can be so readily identified, when so few authenticated cases have thus far been reported. The clear cut symptom complex produced by insulin overdosage, and more satisfactory laboratory facilities, have simplified the recognition of the condition. Whether the term "hyperinsulinism" as first used by Seale Harris will continue to be used or whether the designation "spontaneous hypoglycemia" may be a more correct term, especially for the milder types, the future must decide. The multiplicity and variability of the symptoms of hyperinsulinism recall the days when the various forms of thyroid disturbances had not yet been properly correlated and classified. It does not require a far stretch of the imagination to assume that hyperactivity of the islets of Langerhans may logically occur as well as its counterpart, an inadequate

Harris, Seale:  Hyperinsulinism and Dysinsulinism ,  J. A. M. A. 83: 729-733 ( (Sept. 6) ) 1924.Crossref
Wilder, R. M.; Allan, F. N.; Power, M. H., and Robertson, H. E.:  Carcinoma of the Islands of the Pancreas ,  J. A. M. A. 89: 348-355 ( (July 30) ) 1927.Crossref
Howland, Goldwin; Campbell, W. R.; Maltby, E. J., and Robinson, W. L.:  Dysinsulinism: Convulsion and Coma Due to Islet Cell Tumor of the Pancreas, with Operation and Cure ,  J. A. M. A. 93: 674-678 ( (Aug. 31) ) 1929.Crossref
McClenahan, W. U., and Norris, G. W.:  Adenoma of the Islands of Langerhans with Associated Hypoglycemia ,  Am. J. M. Sc. 177: 93 ( (Jan.) ) 1929.Crossref
Thalhimer, William; and Murphy, F. D.:  Carcinoma of the Islands of the Pancreas: Hyperinsulinism and Hypoglycemia ,  J. A. M. A. 91: 89 ( (July 14) ) 1928.Crossref
Krause, F.:  Hyperinsulinism mit hypoglykämischen Symptomenkomplex ,  Klin. Wchnschr. 9: 2346 ( (Dec. 13) ) 1930.Crossref
Finney, J. M. T., and Finney, J. M. T., Jr.:  Resecting of the Pancreas ,  Ann. Surg. 88: 584-592 ( (Sept.) ) 1928.Crossref
Nielsen, J. M., and Eggleston, E. L.:  Functional Dysinsulinism with Epileptiform Seizures ,  J. A. M. A. 94: 860-863 ( (March 22) ) 1930.Crossref
Valuable assistance was rendered by Dr. H. I. Katz in collecting the data for this report.