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Numerous theories are propounded as to the hematologic defect in cases of hemophilia. Howell1 suggests that the trouble lies in the platelets, which, although morphologically normal in number and structure, fail to yield the cephalin necessary for the clotting process to go on normally. Recently Birch2 confirmed this theory by demonstrating that the platelets of two hemophiliac brothers were much more resistant to anisotonic salt solutions than were normal platelets. In the same paper she called attention to the fact that the female transmits the tendency toward the disease from her father to her son, but as yet no authentic case of hemophilia has been reported in a female. She reasoned that the female must have the tendency toward the disease herself, but that there is something in the female make-up which the male does not have which represses the development of the clinical manifestations of hemophilia. The
Foord AG, Dysart BR. TREATMENT OF HEMOPHILIA BY AN OVARIAN EXTRACT BY BIRCH'S METHOD. JAMA. 1932;98(17):1444–1445. doi:10.1001/jama.1932.27320430002008a
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