Importance
Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease.
Objective
To synthesize the evidence on benefits and harms of behavioral counseling interventions to promote a healthy diet and physical activity in adults without known cardiovascular disease (CVD) risk factors to inform a US Preventive Services Task Force recommendation.
Data Sources
MEDLINE, PsycINFO, and the Cochrane Central Register of Controlled Trials through February 2021, with ongoing surveillance through February 2022.
Study Selection
Randomized clinical trials (RCTs) of behavioral counseling interventions targeting improved diet, increased physical activity, or decreased sedentary time among adults without known elevated blood pressure, elevated lipid levels, or impaired fasting glucose.
Data Extraction and Synthesis
Independent data abstraction and study quality rating and random effects meta-analysis.
Main Outcomes and Measures
CVD events, CVD risk factors, diet and physical activity measures, and harms.
Results
One-hundred thirteen RCTs were included (N = 129 993). Three RCTs reported CVD-related outcomes: 1 study (n = 47 179) found no significant differences between groups on any CVD outcome at up to 13.4 years of follow-up; a combined analysis of the other 2 RCTs (n = 1203) found a statistically significant association of the intervention with nonfatal CVD events (hazard ratio, 0.27 [95% CI, 0.08 to 0.88]) and fatal CVD events (hazard ratio, 0.31 [95% CI, 0.11 to 0.93]) at 4 years. Diet and physical activity behavioral counseling interventions were associated with small, statistically significant reductions in continuous measures of blood pressure (systolic mean difference, −0.8 [95% CI, −1.3 to −0.3]; 23 RCTs [n = 57 079]; diastolic mean difference, −0.4 [95% CI, −0.8 to −0.0]; 24 RCTs [n = 57 148]), low-density lipoprotein cholesterol level (mean difference, 2.2 mg/dL [95% CI, −3.8 to −0.6]; 15 RCTs [n = 6350]), adiposity-related outcomes (body mass index mean difference, −0.3 [95% CI, −0.5 to −0.1]; 27 RCTs [n = 59 239]), dietary outcomes, and physical activity at 6 months to 1.5 years of follow-up vs control conditions. There was no evidence of greater harm among intervention vs control groups.
Conclusions and Relevance
Healthy diet and physical activity behavioral counseling interventions for persons without a known risk of CVD were associated with small but statistically significant benefits across a variety of important intermediate health outcomes and small to moderate effects on dietary and physical activity behaviors. There was limited evidence regarding the long-term health outcomes or harmful effects of these interventions.
Despite evidence that healthy dietary patterns, physical activity, and limited sedentary time are associated with reduced cardiovascular morbidity and mortality, most US adults do not meet national recommendations for these behaviors.1-3 Behavioral interventions occurring in or referred from primary care may be one strategy to improve these behaviors and subsequently prevent poor cardiovascular outcomes.
The US Preventive Services Task Force (USPSTF) has several recommendations related to preventing cardiovascular disease (CVD), including guidance on healthy lifestyle counseling,4,5 tobacco cessation,6 weight loss,7 aspirin use,8 statin use,9 and screening for and treatment of high or abnormal levels of blood pressure10 and glucose.11 In a 2017 recommendation statement, the USPSTF provided a C recommendation that clinicians may choose to selectively counsel adults without known cardiovascular risk factors about healthful diet and physical activity for the primary prevention of CVD.4 The purpose of this review was to update the previous review12,13 on the benefits and harms of behavioral counseling interventions for healthy diet, physical activity, or sedentary behavior to inform an updated USPSTF recommendation statement on this topic. For the purposes of this review, cardiovascular risk factors included elevated blood pressure, elevated lipid levels, or impaired fasting glucose.
This review addressed 4 key questions (KQs) (Figure 1). A full research plan was published prior to conducting the review.15 Methodological details including study selection, a list of excluded studies, additional data analysis methods, detailed study-level results for all outcomes, and contextual observational data are available in the full evidence report.16
Data Sources and Searches
To identify studies published since the previous review,12 literature searches were conducted from 2016 through February 2021 in MEDLINE, PsycINFO, and the Cochrane Central Register of Controlled Trials (eMethods in the Supplement). Additional studies were sought by reviewing reference lists of other systematic reviews. Ongoing surveillance was conducted to identify newly published studies that might affect the findings of the review. This was accomplished through article alerts and targeted searches of select clinical journals.17 The last surveillance on February 9, 2022, identified no new studies.
Two reviewers independently evaluated citations and full-text articles against prespecified inclusion criteria (eTable 1 in the Supplement). Disagreements were resolved by discussion and consensus. The review was limited to fair- and good-quality randomized clinical trials (RCTs) that evaluated the effectiveness of primary care–relevant interventions of behavioral interventions focused on healthy diet, physical activity, sedentary behavior, or a combination of these behaviors. RCTs were included if they were conducted among adults 18 years or older without known CVD, diabetes, or CVD risk factors. As such, trials were excluded that (1) targeted persons with known CVD, hypertension or elevated blood pressure (high blood pressure stage 1 [systolic blood pressure [SBP] 130 mm Hg or diastolic blood pressure [DBP] 80-89 mm Hg]), dyslipidemia, diabetes, impaired fasting glucose or glucose tolerance, or a combination of these factors; (2) targeted persons categorized as high risk based on a cardiovascular risk assessment tool; or (3) generically stated that participants must have 1 or more CVD risk factors to be included. Trials were included if they were among persons who may be at elevated risk for CVD based on factors such as age, race and ethnicity, family history of CVD, overweight or obesity, or history of gestational diabetes. Studies with a primary aim of weight loss or weight management were excluded, because this evidence is covered by a separate systematic review conducted for the USPSTF.18 Studies had to report at least 1 health outcome (eg, CVD events, mortality), intermediate outcome (eg, blood pressure, lipid levels, glucose levels, adiposity), or behavioral outcome (eg, dietary intake, physical activity) or report adverse events (eg, serious harm, injury) related to the intervention. Comparative effectiveness trials without a true control group were excluded.
Data Extraction and Quality Assessment
Two reviewers independently assessed the methodological quality of each study as good, fair, or poor using predefined criteria developed by the USPSTF (eTable 2 in the Supplement). Discrepancies were resolved through consensus. Poor-quality studies with critical methodological limitations were excluded and typically had several major risks of bias, including very high or differential attrition between groups, substantial lack of baseline comparability between groups without adjustment for those variables, possible selective reporting, or inappropriate exclusion of participants from analyses.
One reviewer abstracted data about each study’s design, population, interventions, and outcomes and a second checked data abstraction for accuracy.
Data Synthesis and Analysis
The strength of evidence was rated for each KQ using the approach described in the Methods Guide for Effectiveness and Comparative Effectiveness Reviews,19 based on the number, quality, and size of studies as well as the consistency (similarity of effect direction and size) and precision (degree of certainty around an estimate) of the results between studies.
Data were synthesized separately for each KQ. The data on health outcomes (KQ1) and adverse events (KQ4) did not allow for quantitative pooling because of the limited number of contributing studies, so those data were summarized in tables and narratively. For intermediate health outcomes (KQ2) and behavioral outcomes (KQ3), random-effects meta-analyses were performed to account for the variability of the studies.20 The restricted maximum likelihood method with the Knapp-Hartung correction was applied in meta-analyses.21,22 Crude effect estimates were calculated if between-group results were not reported and adjusted effect estimates were favored over unadjusted. Within each study, the follow-up time point closest to 12 months was pooled. The results of other time points are presented in tabular format in the full report.16
The presence of statistical heterogeneity among the studies was assessed using standard χ2 tests, and the magnitude of heterogeneity was estimated using the I2 statistic. Meta-regression and stratified analyses were conducted to explore whether there were methodologic, population, or intervention characteristics at the study level that were associated with effect size for the most-reported outcomes of SBP and DBP, low-density lipoprotein cholesterol (LDL-C), fasting glucose, body mass index (BMI, calculated as weight in kilograms divided by square of height in meters), weight, and physical activity. The distribution of trial results was examined with funnel plots, and the Egger test (for continuous data) or Peters test (for binary data) was run to assess whether there was evidence of small-study effects.23,24
Stata version 16.1 (StataCorp) was used for all analyses. All significance testing was 2-sided, and results were considered statistically significant if P < .05.
Two reviewers evaluated 7485 citations and 411 full-text articles against inclusion criteria, and 113 RCTs25-137 (204 articles) met inclusion criteria (Figure 2). A full list of the included studies, including ancillary publications, can be found in the full evidence report.16
Of the RCTs, 60 took place in the US; sample sizes ranged from 32 to 48 835 participants. The mean age of the samples ranged from 18.5 to 79.5 years, and most trials included both men and women. A summary of the study and population characteristics can be found in Table 1. Details of each included study can be found in eTable 3 in the Supplement.
The interventions were variable with 33% focusing on both healthy diet and physical activity, 19% focusing on healthy diet only, and 48% focusing on physical activity alone. Most interventions took place for 6 months or less, and the median number of contacts was 7. A summary of the interventions is available in eTable 4 in the Supplement, and detailed intervention characteristics for each trial are reported in eTable 5 in the Supplement and in the full report.16
Benefits on Health Outcomes
Key Question 1. Do primary care–relevant behavioral counseling interventions to improve diet, increase physical activity, and reduce sedentary behavior improve CVD and related health outcomes (eg, morbidity and mortality) in adults without known CVD risk factors?
Fifteen of the 113 included trials reported health outcomes (n = 58 286). Three good-quality trials (n = 48 382) (with relevant results in 8 publications) reported CVD-related health outcomes.29,82,121,138-142 The 3 trials included the very large Women’s Health Initiative Dietary Modification Trial (WHI-DMT) that tested the effects of a high-intensity (6 or more hours of intervention time) low-fat dietary group counseling intervention among postmenopausal women (n = 47 179 without a history of CVD)121 and the PACE-UP29 and PACE-Lift82 physical activity trials by Harris et al (n = 1203 participants without a previous CVD diagnosis).
Within the WHI-DMT, among women without a history of CVD (96.6% of the full sample), total mortality was not statistically significantly different between intervention and control groups over a median cumulative follow-up of 8.5 years (hazard ratio [HR], 0.96 [95% CI, 0.88 to 1.04]) or 13.4 years (HR, 0.97 [95% CI, 0.94 to 1.01]).140 Likewise, time-to-event analyses did not show significant differences between intervention and comparison groups for coronary heart disease (CHD, defined as nonfatal myocardial infarction plus CHD death), total stroke (ischemic plus hemorrhagic stroke), or total CVD events (CHD plus coronary artery bypass graft surgery or percutaneous coronary intervention plus stroke), either over the intervention period (8.5 years) or over longer follow-up (13.4 years).140
When data from both the PACE-UP and PACE-Lift trials were combined, there was a statistically significant intervention association with nonfatal CVD events (HR, 0.27 [95% CI, 0.08 to 0.88]; P = .03). When fatal cardiovascular events were included and trial data were combined, results were similar (HR, 0.31 [95% CI, 0.11 to 0.93]; P = .04).139
Fifteen trials reported health-related quality of life outcomes, using various measures.28,29,34,48,68,76,79,82,93,94,107,124,130,136,143 While many studies showed improvements in quality of life among intervention participants, only 3 trials demonstrated statistically significant differences between intervention and control groups on at least 1 quality of life subscale at 6 months’ or more follow-up.68,93,143 In most cases, very small improvements (eg, less than a 1-point improvement on the SF-36 [36-Item Short Form Health Survey] score) were seen in both intervention and control groups.
Benefits on Intermediate CVD Outcomes
Key Question 2. Do primary care–relevant behavioral counseling interventions to improve diet, increase physical activity, and reduce sedentary behavior improve intermediate outcomes associated with CVD (eg, blood pressure, lipid levels, blood glucose levels, and body mass index) in adults without known CVD risk factors?
Forty-three of the included trials (n = 77 965) reported the effects of a behavioral intervention on at least 1 intermediate health outcome at 6 months or more of follow-up. When results of these trials were pooled in meta-analyses, healthy diet and physical activity interventions were associated with small but statistically significant improvements in blood pressure, LDL-C level, and all measures of adiposity (BMI, weight, waist circumference) compared with controls at 6 months or more (Table 2).
Individually, very few of the trials found statistically significant differences in changes in SBP or DBP between intervention and control groups. However, the pooled mean difference between groups in blood pressure reductions showed statistically significant associations with mean differences of −0.80 mm Hg for SBP (95% CI, −1.30 to −0.31; 23 RCTs [n = 57 079]; I2 = 11.3%) (eFigure 1 in the Supplement) and −0.42 mm Hg for DBP (95% CI, −0.80 to −0.04; 24 RCTs [n = 57 148]; I2 = 35.8%) (eFigure 2 in the Supplement), respectively, at 6 to 18 months compared with controls. Results of meta-regressions and subgroup analyses based on various study, population, and intervention characteristics showed that there were consistent intervention effects on SBP and DBP regardless of these varying characteristics.
For LDL-C, meta-analysis of 15 trials resulted in a statistically significant association, with a mean difference in change of −2.20 mg/dL (approximately 0.057 mmol/L) between groups at 6 to 18 months of follow-up (95% CI, −3.80 to −0.60; n = 6350; I2 = 25.7%) (eFigure 3 in the Supplement). When stratified by intervention intensity, this decrease was significant only among the 8 high-intensity interventions, with a mean difference of −3.88 mg/dL (95% CI, −6.15 to −1.61) between groups. Similarly, a dose-response association was seen, with greater effect sizes associated with increasing duration of the intervention, the number of total intervention sessions, and the number of in-person sessions. There was no significant association between healthy diet, physical activity interventions, or both and levels of total cholesterol or high-density lipoprotein cholesterol in pooled analyses.
There were inconsistent results across studies that reported mean differences in changes in fasting glucose levels, and with few exceptions93,115 none of the individual trials reported statistically significant differences in fasting glucose changes at 6 months or more follow-up. Furthermore, a meta-analysis of 14 trials found no significant association between interventions and changes in fasting glucose levels vs control groups at 6 to 12 months (mean difference, −0.34 mg/dL [95% CI, −1.24 to 0.55] [0.02 mmol/L {95% CI, −0.07 to 0.03 mmol/L}]; n = 7468; I2 = 42.7%).
Although trials that addressed weight loss as a direct goal of the interventions were excluded, the included trials reported small improvements in BMI, weight, and waist circumference (Table 2). Considerable statistical heterogeneity (I 2> 90%) was present in all analyses because of wide variation in effect estimates and precision around those estimates, which likely reflects clinical variability among the included studies. The meta-analysis of BMI measures showed a pooled difference in mean change of −0.32 (95% CI, −0.51 to −0.13; 27 RCTs [n = 59 239]; I2 = 94.6%) related to healthy diet and physical activity interventions (eFigure 4 in the Supplement). The subset of 12 high-intensity interventions consistently showed benefit of the interventions on BMI, with a pooled difference in mean change of −0.69 supporting the intervention (95% CI, −0.99 to −0.40); no such benefit was seen among the subsets of medium- or low-intensity interventions (eFigure 4 in the Supplement). Furthermore, a dose-response association was seen, with increasing intensity (ie, total minutes of intervention contact) and the total number of in-person intervention sessions being statistically significantly associated with increasing effect estimates in meta-regression. A separate meta-analysis showed a statistically significant association with weight in favor of behavioral interventions over control conditions, although again the statistical heterogeneity was considerable (mean difference, −1.07 kg [95% CI, −1.62 to −0.52]; 24 RCTs [n = 51 812]; I2 = 91.2%) (eFigure 5 in the Supplement). This finding translates into a mean difference of −2.4 lb (95% CI, −3.6 to −1.1).
Benefits on Health Behaviors
Key Question 3. Do primary care–relevant behavioral counseling interventions to improve diet, increase physical activity, and reduce sedentary behavior improve intermediate behavioral outcomes (eg, diet, physical activity, and sedentary behavior) in adults without known CVD risk factors?
All but 426,47,123,134 of the 113 included trials were included for KQ3 (n = 125 878); 45 trials (n = 89 140) reported 1 or more dietary outcomes and 87 trials (n = 54 534) reported 1 or more measures of physical activity. The specific behavioral outcomes, measures, and units of measurement were highly variable across the included trials.
Between-group differences in mean change for dietary outcomes showed consistent benefit of the intervention vs control groups, but the precision in the magnitude of effects was variable across the trials that reported each respective outcome (Table 3). Furthermore, there was considerable statistical heterogeneity (I2 > 90%) present in most meta-analyses. Nevertheless, meta-analysis indicated statistically significant associations between healthy diet counseling interventions and measures of saturated fat (standardized mean difference [SMD], −0.53 [95% CI, −0.78 to −0.27]; 16 RCTs [n = 48 661]; I2 = 97.4%), fruit and vegetables (mean difference, 1.11 servings/d [95% CI, 0.41 to 1.81]; 17 RCTs [n = 53 711]; I2 = 99.3%), and fiber (SMD, 0.24 [95% CI, 0.05 to 0.43]; 13 RCTs [n = 47 571]; I2 = 93.9%) intake.
The meta-analysis of the SMD in change in continuous measures of physical activity (eg, minutes per week, kcal/kg per day, steps per day) showed a small but statistically significant association between physical activity interventions and an increase in physical activity levels compared with controls at 6 to 12 months of follow-up (SMD, 0.19 [95% CI, 0.14 to 0.25]; 59 RCTs [n = 20 801]; I2 = 65.4%) (Table 3). Among the 37 trials that reported minutes per week of physical activity, this change amounted to approximately 33 additional minutes of physical activity per week for the intervention group compared with the control group (mean difference, 33.0 min/wk [95% CI, 21.9 to 44.2]; n = 15 015; I2 = 76.0%). Twenty-four trials reported the proportion of participants meeting recommended levels of physical activity (at least 150 minutes of moderate to vigorous–intensity physical activity) at 6 months to 2 years of follow-up. The meta-analysis of all 24 trials showed that physical activity interventions were associated with a higher odds of meeting physical activity recommendations at 6 to 12 months of follow-up compared with control interventions (pooled odds ratio, 1.41 [95% CI, 1.18 to 1.67]; 24 RCTs [n = 17 338]; I2 = 55.1%).
Sixteen trials (n = 5867) reported measures of sedentary behavior, independent of physical activity.29,33,34,39-41,46,50,62,82,89,102,116,119,130,136 The measures and results were highly variable. When measures were combined, the standardized effect of the interventions did not show a statistically significant difference between groups at 6 to 12 months of follow-up, although the effect was in the direction of intervention benefit (SMD, −0.22 [95% CI, −0.47 to 0.03]; 15 trials [n = 3479]; I2 = 89.9%).
Key Question 4. What are the harms of primary care–relevant behavioral counseling interventions to improve diet, increase physical activity, and reduce sedentary behavior in adults without known CVD risk factors?
Twenty-three of the 113 included trials specifically mentioned the occurrence of adverse events or lack of adverse events (n = 12 452). Thirteen trials reported adverse events or serious adverse events of any kind,29-31,33,41,48,51,56,62,82,114,132,136 although 7 of these trials only stated that no adverse events were reported or that no adverse events related to the trial were evident but no additional details were provided.33,41,51,62,114,132,136 The other 6 trials found that rates of adverse events were relatively similar across groups (ranging from 22.6% to 80% of intervention group participants and 25.4% to 71% of control group participants), and none reported rates of any adverse events to be statistically significantly different between groups.29-31,48,56,82 Twelve trials reported the incidence of musculoskeletal injuries, fractures, or falls and found primarily no differences between treatment groups.29,42,59,68,82,92,94,96,107,120,130,134
This review included 113 unique trials, of which 33 (29%) were published since the 2017 USPSTF review.12 The pooled effect estimates found in the updated systematic review are consistent in magnitude with those from the 2017 review on this topic12 and lower in magnitude than the effects seen with the 2020 review among persons at high risk for CVD.144 The evidence is summarized in Table 4.
By design, the current review excluded studies that recruited individuals at high risk of CVD—defined only by the presence of elevated blood pressure, elevated lipid levels, or impaired fasting glucose. In all other ways, the persons represented in the trials exhibited a broad range of sociodemographic and behavioral characteristics. Very few trials reported the underlying CVD risk of participants at baseline (ie, the proportion of participants with existing hypertension or dyslipidemia). While this review was designed to represent persons not at risk of CVD, it is possible that not all participants within the included evidence were of average CVD risk; at best, it is known that they were not recruited into these trials because of an underlying risk.
Although most studies recruited participants directly (via invitations through primary care, the broader health care system, or some other convenience sample), the adults who took part in these studies may have been more motivated to change their behaviors than those in the general community. Given the broad representation across population characteristics and that most of the studies took place in the US, the findings of this review are likely generalizable to a US primary care population, although the magnitude of the effects may be lower when applied to general practice.
Based on the included literature, it is not possible to define either the minimum necessary intervention components for an effective intervention or identify a single optimal or representative intervention. No two studies had the same goals, behavior change messages, modes of delivery, or delivery schedule. Across all interventions, most included tailored advice and materials and encouraged goal setting and self-monitoring. A substantial number of the trials, including many of the newer studies, used interventions that were administered completely remotely—either via telephone or printed materials—or were computer- or e-mail-based.
Although there was general consistency in the direction of beneficial effects among all the trials, there was variation in the magnitude of the effects, and there was often wide variation within studies. This variation likely reflects that even within studies, some participants can achieve greater change while others may not. Most likely, the ideal counseling intervention for any given person will depend on consideration of their specific clinical characteristics, including existing diet and physical activity behaviors, and the larger context of other prevention or screening priorities, given the limited time for a typical primary care encounter. Furthermore, it is likely that there are many social determinants of health at play (eg, food insecurity, low-income status) that may affect the size of the effects seen. Very limited data were provided on the underlying social conditions (ie, risks and inequities) present among the included samples.
This review has several limitations. First, few studies were included that reported measures of intermediate cardiometabolic outcomes, and even fewer were included that reported longer term health outcomes. Because the prevalence and rate of these health outcomes are lower in lower-risk groups (by definition), these studies require larger sample sizes and longer follow-up to observe an effect of an intervention in a low-risk group of participants.145 Second, very few of the included trials explored whether effectiveness of the interventions varied among important populations. Such analyses could assist in identifying groups of adults who might benefit more and help reduce disparities that exist related to cardiovascular-related health. Third, given that behavioral outcomes were the primary outcomes in almost all the included studies, there is a need for better standardization related to the collection and reporting of these outcomes. Fourth, given the strong evidence that greater time spent in sedentary behavior is independently associated with all-cause and CVD mortality146 and clear guidance that individuals should limit the amount of time spent being sedentary,147 there is a need for trials evaluating interventions designed to reduce sedentary behaviors.
Healthy diet and physical activity behavioral interventions for persons without a known risk of CVD were associated with small but statistically significant benefits across a variety of important intermediate health outcomes and small to moderate effects on dietary and physical activity behaviors. There was limited evidence regarding the long-term health outcomes or harmful effects of these interventions.
Corresponding Author: Carrie D. Patnode, PhD, MPH, Kaiser Permanente Evidence-based Practice Center, The Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227 (Carrie.D.Patnode@kpchr.org).
Accepted for Publication: April 19, 2022.
Author Contributions: Dr Patnode had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Patnode.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Patnode, Iacocca.
Critical revision of the manuscript for important intellectual content: Patnode, Redmond, Henninger.
Statistical analysis: Patnode, Redmond.
Obtained funding: Patnode.
Administrative, technical, or material support: All authors.
Supervision: Patnode.
Conflict of Interest Disclosures: None reported.
Funding/Support: This research was funded under contract HHSA 290201500007I-EPC5, Task Order 9, from the Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services, under a contract to support the US Preventive Services Task Force (USPSTF).
Role of the Funder/Sponsor: Investigators worked with USPSTF members and AHRQ staff to develop the scope, analytic framework, and key questions for this review. AHRQ had no role in study selection, quality assessment, or synthesis. AHRQ staff provided project oversight, reviewed the report to ensure that the analysis met methodological standards, and distributed the draft for peer review. Otherwise, AHRQ had no role in the conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript findings. The opinions expressed in this document are those of the authors and do not reflect the official position of AHRQ or the US Department of Health and Human Services.
Additional Contributions: We gratefully acknowledge the following individuals for their contributions to this project: Justin A. Mills, MD, MPH (AHRQ); current and former members of the USPSTF who contributed to topic deliberations; and Evidence-based Practice Center staff members Melinda Davies, MA, and Jill Pope for technical and editorial assistance at the Kaiser Permanente Center for Health Research. USPSTF members, peer reviewers, and federal partner reviewers did not receive financial compensation for their contributions.
Additional Information: A draft version of this evidence report underwent external peer review from 4 content experts (Tess Harris, MD [St George’s University of London]; Penny Kris-Etherton, PhD, RD [Penn State University]; Karen Goldstein, MD [Duke University]; and Jill Huber, MD [Mayo Clinic]) and 4 federal partners (Centers for Disease Control and Prevention; Office of Research on Women’s Health; National Heart, Lung, and Blood Institute; and National Institute of Nursing Research). Comments were presented to the USPSTF during its deliberation of the evidence and were considered in preparing the final evidence review.
Editorial Disclaimer: This evidence report is presented as a document in support of the accompanying USPSTF recommendation statement. It did not undergo additional peer review after submission to JAMA.
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