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April 30, 1932


JAMA. 1932;98(18):1581-1582. doi:10.1001/jama.1932.02730440061021

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Smallpox Without Exanthem  Dr. De Jongh of The Hague gave a detailed account in the Klinische Wochenschrift, Oct. 25, 1930, of the epidemic of smallpox that raged in the Netherlands in 1929. The epidemic was started by a sailor who returned from the East Indies with smallpox, from which he had partially recovered, and gave rise to a total of 318 cases at Rotterdam and 62 at The Hague, where the patients were cared for in an isolation hospital by 42 women nurses. One of the nurses came down with the disease, with a slight but frank exanthem, and twelve nurses had smallpox without exanthem. Most of the patients had been revaccinated a short time before they took care of the smallpox patients. There is reason to think that they presented an allergic reaction toward the smallpox virus. This idea is borne out by the shortness of the incubation period