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Article
May 7, 1932

THE NEED OF LARGER DOSES OF VIOSTEROL IN SEVERE RICKETS (OSTEOMALACIA TYPE): A COMPARATIVE STUDY OF THE EFFICACY OF VIOSTEROL AND COD LIVER OIL

Author Affiliations

CHICAGO

From the Department of Pediatrics of the Michael Reese Hospital.

JAMA. 1932;98(19):1637-1640. doi:10.1001/jama.1932.02730450031010
Abstract

Much of the earlier apprehension concerning the toxic effects of viosterol (irradiated ergosterol) has been dispelled by more recent clinical observations. The early reports of A. F. Hess, Lewis and Rivkin,1 Pfannenstiel,2 Kreitmair and Moll,3 Bamberger and Spranger,4 and numerous others concerning the toxicity of viosterol are too well known to be reviewed at this time. It is questionable how reliable the early clinical observations and animal experiments may be considered, as most of the preparations employed before 1929 were standardized gravimetrically and not biologically, and accordingly could not have been constant in potency. More recent reports of A. F. Hess,1 J. H. Hess, Poncher, Dale and Klein,5 Grayzel, Shear and Kramer,6 and others offer sufficient evidence that viosterol may be given over long periods in doses many times as large as those usually recommended without any danger

Two brothers of Armenian parentage,

References
1.
Hess, A. F.; Lewis, J. M., and Rivkin, Helen:  The Status of the Therapeutics of Irradiated Ergosterol ,  J. A. M. A. 93: 661 ( (Aug. 31) ) 1929.Crossref
2.
Hess, A. F.; Lewis, J. M.; MacLeod, F. L., and Thomas, B. H.:  Antirachitic Potency of Cows Fed Irradiated Yeast or Ergosterol ,  J. A. M. A. 97: 370 ( (Aug. 8) ) 1931.Crossref
3.
Pfannenstiel, W.:  Lancet 2: 845 ( (Oct. 20) ) 1928.Crossref
4.
Kreitmair, H., and Moll, T.:  München. med. Wchnschr. 75: 637 ( (April 13) ) 1928.
5.
Bamberger and Spranger:  Deutsche med. Wchnschr. 54: 1116 ( (July 6) ) 1928.Crossref
6.
Hess, J. H.; Poncher, H. G.; Dale, M. L., and Klein, R. I.:  Viosterol (Irradiated Ergosterol) ,  J. A. M. A. 95: 316 ( (Aug. 2) ) 1930.Crossref
7.
Hess, J. H.: Abstr.  Am. J. Dis Child. 41: 1228 ( (May) )
8.
42: 488 (Aug.) 1931
9.
Tr. Second Internat. Cong. Stockholm, 1930.
10.
Grayzel, H. G.; Shear, M. J., and Kramer, Benjamin:  Am. Rev. Tuberc. 24: 106 ( (Aug.) ) 1931.
11.
Determinations were made in the department of chemistry (calcium by the Clark-Collip modification of the Kramer-Tisdall method and phosphorus by the Briggs modification of the Bell-Doisy method).
12.
Furnished through the courtesy of Mead Johnson & Co., as were all of the preparations used in our investigation.
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