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Article
June 4, 1932

THE EFFECTIVENESS OF PENTOBARBITAL IN ANTIDOTING STRYCHNINE POISONING IN THE RABBIT

Author Affiliations

Cleveland

From the Department of Pharmacology of the Western Reserve University School of Medicine.

JAMA. 1932;98(23):1980-1981. doi:10.1001/jama.1932.27320490001008
Abstract

Following the report of Dawson and Taft1 in which several barbitals were shown to antagonize effectively the fatal reaction of the rabbit to from 1 to 1½ lethal doses of strychnine, an attempt was made to adapt the results of their study for inclusion in our course in pharmacodynamics. The observations of these authors in relation to pentobarbital were confirmed; the other members of the group were not tested. The

ease with which the antagonism may be demonstrated and the remarkable protective effect of pentobarbital against strychnine poisoning (up to thirty-five times the minimum lethal dose) appeared to merit publication of a representative protocol and a summary of the results obtained with various dosages

of the alkaloid simply as an extension of the studies of Dawson and Taft. Recently, and subsequent to completion of these observations, Swanson2 observed that amytal antidotes approximately 10 lethal doses of strychnine in

References
1.
Dawson, W. T., and Taft, C. H., Jr.:  Proc. Soc. Exper. Biol. & Med. 28: 917 ( (June) ) 1931.
2.
Swanson, E. E.:  J. Lab. & Clin. Med. 17:325 ( (Jan.) ) 1932.
3.
Haggard, H. W., and Greenberg, L. A.:  Antidotes for Strychnine Poisoning ,  J. A. M. A. 98:1133 ( (April 2) ) 1932.
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