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Article
July 9, 1932

A CONDITION SIMULATING HUMAN SCLERODERMA IN RATS INJECTED WITH PARATHYROID HORMONE

Author Affiliations

BALTIMORE

From the Department of Bio-Chemistry, School of Hygiene and Public Health, the Johns Hopkins University.

JAMA. 1932;99(2):108. doi:10.1001/jama.1932.02740540016006
Abstract

In the course of the collection of experimental data on rats injected with parathyroid hormone1 it became evident that young suckling rats receiving in some cases only a single injection of 5 units of parathyroid extract intraperitoneally develop within some days a specific skin disease.

This condition presents itself first as a hardening of the skin on the back, extending bilaterally from the head to the lower border of the ribs. Within two or three days the hair over these areas begins to fall out and concomitant with these phenomena the skin becomes harder and thicker. Ulceration of these symmetrically arranged affected areas takes place in some parts, and finally after healing a bare, hairless, atrophic skin results.

When examined histologically, the areas under consideration show a marked hypertrophy of the fibrous tissue in the skin, between the epithelium and the layer of the hair follicles. The areas of

References
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The preparation used was parathyroid extract-Collip (para-thormone-Lilly), provided by Eli Lilly & Co.
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