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Article
July 9, 1932

HYPOPHYSEAL CACHEXIA (SIMMONDS' DISEASE): WITH REPORT OF THREE CASES

Author Affiliations

ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan Medical School.

JAMA. 1932;99(2):110-114. doi:10.1001/jama.1932.02740540018008
Abstract

In 1914, Simmonds1 reconstructed from necropsy studies of two cases the clinical syndrome which results from destruction of the anterior lobe of the hypophysis. Since that time a number of cases have been described in the German literature, although none appeared in the English language until Graham and Farquharson2 reported four cases in 1931.

Clinically the syndrome is characterized by premature senescence, generalized atrophy of all tissues, gradual failure of the body functions, mental torpor, apathy and death. The literature on the disease was reviewed to 1922 by Knoll,3 and to 1930 by Werner Merz.4

ETIOLOGY  The destruction of the anterior lobe of the hypophysis may be caused by a number of primary and secondary conditions, and a review of twenty-four selected cases with autopsy observations from the literature suggests the following principal factors in the order of their importance: puerperal sepsis (septic embolus), 9; syphilis,

References
1.
Simmonds, Morris:  Ueber Hypophysisschwund mit todlichem Ausgang ,  Deutsche med. Wchnschr. , 1914, p. 401
2.
 Ueber Kachexia hypophysaren Usprungs , Simmonds Deutsche med. Wchnschr. 421, 190, 1916.Crossref
3.
Graham, D. A. L., and Farquharson, R. F.:  Simmonds' Disease ,  Tr. A. Am. Physicians , 1931
4.
abstr.  J. A. M. A. 96: 1987 ( (June 6) ) 1931.
5.
Knoll, W.:  Beitrag zum Bilde der hypophysaren Kachexia ,  Wien. Arch. f. inn. Med. 4: 555, 1921.
6.
Merz, Werner:  Beitrag zur Frage der Enktehang der hypophysaren Kachexia ,  Frankfurt. Ztschr. f. Path. 40: 452, 1930.
7.
Simmonds, Morris:  Ueber Embolic processes in der Hypophysen ,  Virchows Arch. f. path. Anat. 217: 226, 1914.
8.
Budde, Max:  Zur Kenntnis der bosartigen Hypophysengeschwulste und hypophysaren Kachexia ,  Frankfurt. Ztschr. f. Path. 25: 18, 1921.
9.
Oppenheimer, B. S., in discussion on Graham and Farquharson (footnote 2).
10.
Erdheim, J.:  Zusammenfassung über die Hypophysengewachse und Krankheiten ,  Ergebn. d. Path. 21: 547.
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